Objectives: The aim of this study was to investigate the association between an exaggerated blood pressure (BP) response to exercise and augmented angiotensin (Ang) II rise during exercise. Background: Although a central pressor effect of Ang II has been implicated in the pathogenesis of hypertension, the relationship between Ang II and exaggerated BP response to exercise is unclear. Methods: Thirty-six subjects with an exaggerated BP response to exercise (18 men, age 50 ± 16 years, Group II) were compared with 36 age- and gender-matched control subjects (18 men, age 50 ± 16 years, Group I) with normal BP reactivity. The subjects who had resting BP ≥140/90 mm Hg or were treated with any antihypertensive drugs were excluded. The blood was sampled at rest and immediately after peak exercise for measurement of renin, Ang II, aldosterone, and catecholamine. Results: At rest, there were no significant differences in BP, renin, aldosterone, and catecholamine levels between the 2 groups. The renin, aldosterone, and catecholamine were increased during exercise, but there were no significant differences between the groups. However, log Ang II at rest (0.78 ± 0.32 vs. 0.98 ± 0.38, p = 0.004) and peak exercise (0.84 ± 0.35 vs. 1.17 ± 0.51, p < 0.001) and the magnitude of the increment of log Ang II with exercise (0.06 ± 0.12 vs. 0.19 ± 0.20, p = 0.003) were significantly higher in the exaggerated BP response group. Conclusions: An exaggerated BP response to exercise was associated with augmented rise of Ang II during exercise.
Bibliographical noteFunding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (M10642120001-06N4212-00110).
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine