Exchange-coupled magnetic nanoparticles for efficient heat induction

Jae Hyun Lee, Jung Tak Jang, Jin Sil Choi, Seung Ho Moon, Seung Hyun Noh, Ji Wook Kim, Jin Gyu Kim, Il Sun Kim, Kook In Park, Jinwoo Cheon

Research output: Contribution to journalArticle

757 Citations (Scopus)

Abstract

The conversion of electromagnetic energy into heat by nanoparticles has the potential to be a powerful, non-invasive technique for biotechnology applications such as drug release, disease treatment and remote control of single cell functions, but poor conversion efficiencies have hindered practical applications so far. In this Letter, we demonstrate a significant increase in the efficiency of magnetic thermal induction by nanoparticles. We take advantage of the exchange coupling between a magnetically hard core and magnetically soft shell to tune the magnetic properties of the nanoparticle and maximize the specific loss power, which is a gauge of the conversion efficiency. The optimized core-shell magnetic nanoparticles have specific loss power values that are an order of magnitude larger than conventional iron-oxide nanoparticles. We also perform an antitumour study in mice, and find that the therapeutic efficacy of these nanoparticles is superior to that of a common anticancer drug.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalNature Nanotechnology
Volume6
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Fingerprint

induction
Nanoparticles
heat
nanoparticles
power loss
Conversion efficiency
drugs
remote control
Exchange coupling
biotechnology
Biotechnology
Remote control
Iron oxides
iron oxides
Pharmaceutical Preparations
Electromagnetic waves
Gages
mice
Hot Temperature
Magnetic properties

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Lee, Jae Hyun ; Jang, Jung Tak ; Choi, Jin Sil ; Moon, Seung Ho ; Noh, Seung Hyun ; Kim, Ji Wook ; Kim, Jin Gyu ; Kim, Il Sun ; Park, Kook In ; Cheon, Jinwoo. / Exchange-coupled magnetic nanoparticles for efficient heat induction. In: Nature Nanotechnology. 2011 ; Vol. 6, No. 7. pp. 418-422.
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Lee, JH, Jang, JT, Choi, JS, Moon, SH, Noh, SH, Kim, JW, Kim, JG, Kim, IS, Park, KI & Cheon, J 2011, 'Exchange-coupled magnetic nanoparticles for efficient heat induction', Nature Nanotechnology, vol. 6, no. 7, pp. 418-422. https://doi.org/10.1038/nnano.2011.95

Exchange-coupled magnetic nanoparticles for efficient heat induction. / Lee, Jae Hyun; Jang, Jung Tak; Choi, Jin Sil; Moon, Seung Ho; Noh, Seung Hyun; Kim, Ji Wook; Kim, Jin Gyu; Kim, Il Sun; Park, Kook In; Cheon, Jinwoo.

In: Nature Nanotechnology, Vol. 6, No. 7, 07.2011, p. 418-422.

Research output: Contribution to journalArticle

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