Exchange-coupled magnetic nanoparticles for efficient heat induction

Jae Hyun Lee, Jung Tak Jang, Jin Sil Choi, Seung Ho Moon, Seung Hyun Noh, Ji Wook Kim, Jin Gyu Kim, Il Sun Kim, Kook In Park, Jinwoo Cheon

Research output: Contribution to journalArticlepeer-review

1090 Citations (Scopus)


The conversion of electromagnetic energy into heat by nanoparticles has the potential to be a powerful, non-invasive technique for biotechnology applications such as drug release, disease treatment and remote control of single cell functions, but poor conversion efficiencies have hindered practical applications so far. In this Letter, we demonstrate a significant increase in the efficiency of magnetic thermal induction by nanoparticles. We take advantage of the exchange coupling between a magnetically hard core and magnetically soft shell to tune the magnetic properties of the nanoparticle and maximize the specific loss power, which is a gauge of the conversion efficiency. The optimized core-shell magnetic nanoparticles have specific loss power values that are an order of magnitude larger than conventional iron-oxide nanoparticles. We also perform an antitumour study in mice, and find that the therapeutic efficacy of these nanoparticles is superior to that of a common anticancer drug.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalNature Nanotechnology
Issue number7
Publication statusPublished - 2011 Jul

Bibliographical note

Funding Information:
This work was supported by Creative Research Initiative (2010-0018286), WCU Program (R32-2009-10217) and BK21 Project. The authors thank H. Nah for preliminary SLP measurements and Y. Jo at KBSI for magnetism measurements. K.I.P. was supported by the Stem Cell Research Center and Korea Healthcare Technology R&D Project (A091159).

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering


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