Exercise training improves age-related myocardial metabolic derangement: Proton magnetic resonance spectroscopy study in the rat model

Sang Il Choi, Hyuk Jae Chang, Eun Ju Chun, Seong Bong Cho, Sang Tae Kim, Yeonyee E. Yoon, Sung A. Chang, Jae Hyoung Kim, Cheol Ho Kim, Tae Hwan Lim

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: The objective of this study was to determine whether long-term exercise training will improve age-related cardiac metabolic derangement using proton magnetic resonance (MR) spectroscopy. Materials and Methods: Young and old male Fischer 344 rats were assigned to sedentary controls groups {young control (YC) group-3 months of age: YC, n=10; old control (OC) group-22 months of age: OC, n=10}, and an exercise training group (OT, n=5). After 12-week of treadmill exercise training, MR spectroscopy at 4.7 T was performed to assess myocardial energy metabolism: measurements of myocardial creatine-to-water ratio (Scr/Sw) were performed using the XWIN-NMR software. Results: Exercise capacity was 14.7 minutes greater in OT than that in OC (20.1±1.9 minutes in OT, 5.4±2.3 minutes in OC; p<0.001). The 12-week exercise training rendered the old rats a maximum exercise capacity matching that of untrained YC rats (17.9±1.5 minutes in YC, 20.1±1.9 minutes in OT; p>0.05). The creatine-to-water ratios in the interventricular septa of YC did not differ significantly from that of OT (0.00131±0.00025 vs. 0.00127±0.00031; p=0.37). However, OC showed significant reduction in creatine-to-water ratio compared to OT (0.00096±0.00025 vs. 0.00127±0.00031; p<0.001). Mean total creatine concentrations in the myocardium were similar between YC and OT (13.3±3.6 vs. 11.5±4.1 mmol/kg wet weight; p=0.29). In contrast, the mean total creatine concentration of OC was significantly reduced compared to OT (6.8±3.2 vs. 11.5±4.1 mmol/kg wet weight; p=0.03). Conclusion: Our findings suggest that long-term exercise training in old rats induced prevention of age-related deterioration in myocardial metabolism.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalKorean Circulation Journal
Volume40
Issue number9
DOIs
Publication statusPublished - 2010 Sep 1

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Creatine
Exercise
Control Groups
Water
Weights and Measures
Inbred F344 Rats
Energy Metabolism
Myocardium
Magnetic Resonance Spectroscopy
Software
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Choi, Sang Il ; Chang, Hyuk Jae ; Chun, Eun Ju ; Cho, Seong Bong ; Kim, Sang Tae ; Yoon, Yeonyee E. ; Chang, Sung A. ; Kim, Jae Hyoung ; Kim, Cheol Ho ; Lim, Tae Hwan. / Exercise training improves age-related myocardial metabolic derangement : Proton magnetic resonance spectroscopy study in the rat model. In: Korean Circulation Journal. 2010 ; Vol. 40, No. 9. pp. 454-458.
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abstract = "Background and Objectives: The objective of this study was to determine whether long-term exercise training will improve age-related cardiac metabolic derangement using proton magnetic resonance (MR) spectroscopy. Materials and Methods: Young and old male Fischer 344 rats were assigned to sedentary controls groups {young control (YC) group-3 months of age: YC, n=10; old control (OC) group-22 months of age: OC, n=10}, and an exercise training group (OT, n=5). After 12-week of treadmill exercise training, MR spectroscopy at 4.7 T was performed to assess myocardial energy metabolism: measurements of myocardial creatine-to-water ratio (Scr/Sw) were performed using the XWIN-NMR software. Results: Exercise capacity was 14.7 minutes greater in OT than that in OC (20.1±1.9 minutes in OT, 5.4±2.3 minutes in OC; p<0.001). The 12-week exercise training rendered the old rats a maximum exercise capacity matching that of untrained YC rats (17.9±1.5 minutes in YC, 20.1±1.9 minutes in OT; p>0.05). The creatine-to-water ratios in the interventricular septa of YC did not differ significantly from that of OT (0.00131±0.00025 vs. 0.00127±0.00031; p=0.37). However, OC showed significant reduction in creatine-to-water ratio compared to OT (0.00096±0.00025 vs. 0.00127±0.00031; p<0.001). Mean total creatine concentrations in the myocardium were similar between YC and OT (13.3±3.6 vs. 11.5±4.1 mmol/kg wet weight; p=0.29). In contrast, the mean total creatine concentration of OC was significantly reduced compared to OT (6.8±3.2 vs. 11.5±4.1 mmol/kg wet weight; p=0.03). Conclusion: Our findings suggest that long-term exercise training in old rats induced prevention of age-related deterioration in myocardial metabolism.",
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Exercise training improves age-related myocardial metabolic derangement : Proton magnetic resonance spectroscopy study in the rat model. / Choi, Sang Il; Chang, Hyuk Jae; Chun, Eun Ju; Cho, Seong Bong; Kim, Sang Tae; Yoon, Yeonyee E.; Chang, Sung A.; Kim, Jae Hyoung; Kim, Cheol Ho; Lim, Tae Hwan.

In: Korean Circulation Journal, Vol. 40, No. 9, 01.09.2010, p. 454-458.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise training improves age-related myocardial metabolic derangement

T2 - Proton magnetic resonance spectroscopy study in the rat model

AU - Choi, Sang Il

AU - Chang, Hyuk Jae

AU - Chun, Eun Ju

AU - Cho, Seong Bong

AU - Kim, Sang Tae

AU - Yoon, Yeonyee E.

AU - Chang, Sung A.

AU - Kim, Jae Hyoung

AU - Kim, Cheol Ho

AU - Lim, Tae Hwan

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Background and Objectives: The objective of this study was to determine whether long-term exercise training will improve age-related cardiac metabolic derangement using proton magnetic resonance (MR) spectroscopy. Materials and Methods: Young and old male Fischer 344 rats were assigned to sedentary controls groups {young control (YC) group-3 months of age: YC, n=10; old control (OC) group-22 months of age: OC, n=10}, and an exercise training group (OT, n=5). After 12-week of treadmill exercise training, MR spectroscopy at 4.7 T was performed to assess myocardial energy metabolism: measurements of myocardial creatine-to-water ratio (Scr/Sw) were performed using the XWIN-NMR software. Results: Exercise capacity was 14.7 minutes greater in OT than that in OC (20.1±1.9 minutes in OT, 5.4±2.3 minutes in OC; p<0.001). The 12-week exercise training rendered the old rats a maximum exercise capacity matching that of untrained YC rats (17.9±1.5 minutes in YC, 20.1±1.9 minutes in OT; p>0.05). The creatine-to-water ratios in the interventricular septa of YC did not differ significantly from that of OT (0.00131±0.00025 vs. 0.00127±0.00031; p=0.37). However, OC showed significant reduction in creatine-to-water ratio compared to OT (0.00096±0.00025 vs. 0.00127±0.00031; p<0.001). Mean total creatine concentrations in the myocardium were similar between YC and OT (13.3±3.6 vs. 11.5±4.1 mmol/kg wet weight; p=0.29). In contrast, the mean total creatine concentration of OC was significantly reduced compared to OT (6.8±3.2 vs. 11.5±4.1 mmol/kg wet weight; p=0.03). Conclusion: Our findings suggest that long-term exercise training in old rats induced prevention of age-related deterioration in myocardial metabolism.

AB - Background and Objectives: The objective of this study was to determine whether long-term exercise training will improve age-related cardiac metabolic derangement using proton magnetic resonance (MR) spectroscopy. Materials and Methods: Young and old male Fischer 344 rats were assigned to sedentary controls groups {young control (YC) group-3 months of age: YC, n=10; old control (OC) group-22 months of age: OC, n=10}, and an exercise training group (OT, n=5). After 12-week of treadmill exercise training, MR spectroscopy at 4.7 T was performed to assess myocardial energy metabolism: measurements of myocardial creatine-to-water ratio (Scr/Sw) were performed using the XWIN-NMR software. Results: Exercise capacity was 14.7 minutes greater in OT than that in OC (20.1±1.9 minutes in OT, 5.4±2.3 minutes in OC; p<0.001). The 12-week exercise training rendered the old rats a maximum exercise capacity matching that of untrained YC rats (17.9±1.5 minutes in YC, 20.1±1.9 minutes in OT; p>0.05). The creatine-to-water ratios in the interventricular septa of YC did not differ significantly from that of OT (0.00131±0.00025 vs. 0.00127±0.00031; p=0.37). However, OC showed significant reduction in creatine-to-water ratio compared to OT (0.00096±0.00025 vs. 0.00127±0.00031; p<0.001). Mean total creatine concentrations in the myocardium were similar between YC and OT (13.3±3.6 vs. 11.5±4.1 mmol/kg wet weight; p=0.29). In contrast, the mean total creatine concentration of OC was significantly reduced compared to OT (6.8±3.2 vs. 11.5±4.1 mmol/kg wet weight; p=0.03). Conclusion: Our findings suggest that long-term exercise training in old rats induced prevention of age-related deterioration in myocardial metabolism.

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