Expanding the Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Overlapping Multifocal Choroiditis

Hyun Goo Kang, Tae Young Kim, Min Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee

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4 Citations (Scopus)


Purpose: To evaluate multifocal evanescent white dot syndrome (MEWDS) patients with and without overlapping multifocal choroiditis (MFC). Methods: Thirty-four patients diagnosed between November 2008 and August 2018 at 2 hospitals were retrospectively reviewed. Multimodal imaging including optical coherence tomography angiography (OCTA) was assessed. Results: Twenty-seven (79%) patients were women (overall mean age, 30 years). Five developed MFC lesions in the affected eyes, and one developed MFC in the unaffected fellow eye. Another developed combined MEWDS and MFC in the fellow eye during follow-up. Eyes with MFC had thicker choroids (316.5 and 197.3 µm, respectively; P = .001) at presentation, which became thinner after resolution (P = .043). Those with subfoveal MFC had poor visual prognosis (P = .019). Areas of suspected choriocapillaris flow deficit were identified on OCTA. Conclusion: Some MEWDS patients may develop overlapping MFC in the same or fellow eyes, presenting with increased choroidal thickness which decreased after resolution.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalOcular Immunology and Inflammation
Issue number1
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) under Grant [NRF-2019R1A2C2002393] and by a faculty research grant of Yonsei University College of Medicine [6-2017-0069].

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology


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