Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the first time.
Bibliographical noteFunding Information:
We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry