Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization

Ikyon Kim, Jihyun Choi, Hye Kyoung Won, Ge Hyeoung Lee

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the first time.

Original languageEnglish
Pages (from-to)6863-6867
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number39
DOIs
Publication statusPublished - 2007 Sep 24

Bibliographical note

Funding Information:
We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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