Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma

ChangMoo Kang, Akira Matsushita, Hokyoung Hwang, Yoko Matsuda, Hyunki Kim, Yoshiharu Nakamura, Woo Jung Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study aimed to elucidate the clinicopathological characteristics of resected mucinous cystic neoplasm (MCN) with ovarian-type stroma and identify a surgical approach for MCN treatment, on the basis of Republic of Korean (Yonsei University College of Medicine, Seoul, South Korea) and Japanese (Nippon Medical School, Tokyo, Japan) bi-institutional collaboration. The present study retrospectively reviewed 55 MCNs with ovarian-type stroma using pathological re-examination. Clinicopathological features and preoperative clinical parameters were evaluated to predict malignant alterations in MCNs. The proportion of surgically treated MCNs has recently been increasing. All patients included in the present study were female, with a mean age of 47.9±13.3 years. Mural nodules were noted in 8 patients (14.5%) and the mean cyst size was 6.1±4.2 cm. A total of 9 patients (16.4%) were identified to exhibit non-invasive mucinous cystadenocarcinoma. The number of patients with small tumors (R2=-0.079, P=0.038) and asymptomatic pancreatic MCNs (P=0.022) was significantly increased (P<0.05), which resulted in the more frequent application of minimally invasive surgery (P<0.001). During the follow-up period (mean, 51.6 months; range, 1.1-242.8 months), no recurrence or tumor-associated mortality was identified. The presence of mural nodules (P=0.002) and a tumor size ≥4.5 cm (P=0.027) were identified as potential clinical parameters for predicting malignant transformation. The significance of mural nodules in predicting malignant transformation was increased in large MCNs (≥4.5 cm) of the pancreas compared with small MCNs (<4.5 cm) (P=0.002). Overall, non-invasive pancreatic MCNs are not aggressive, and minimally invasive pancreatectomy may be an effective approach for suitable patients.

Original languageEnglish
Pages (from-to)2451-2458
Number of pages8
JournalOncology Letters
Volume15
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1

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Ovarian Neoplasms
Neoplasms
Mucinous Cystadenocarcinoma
Republic of Korea
Pancreatectomy
Minimally Invasive Surgical Procedures
Tokyo
Medical Schools
Cysts
Pancreas
Japan
Medicine
Recurrence
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kang, C., Matsushita, A., Hwang, H., Matsuda, Y., Kim, H., Nakamura, Y., & Lee, W. J. (2018). Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma. Oncology Letters, 15(2), 2451-2458. https://doi.org/10.3892/ol.2017.7627
Kang, ChangMoo ; Matsushita, Akira ; Hwang, Hokyoung ; Matsuda, Yoko ; Kim, Hyunki ; Nakamura, Yoshiharu ; Lee, Woo Jung. / Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma. In: Oncology Letters. 2018 ; Vol. 15, No. 2. pp. 2451-2458.
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Kang, C, Matsushita, A, Hwang, H, Matsuda, Y, Kim, H, Nakamura, Y & Lee, WJ 2018, 'Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma', Oncology Letters, vol. 15, no. 2, pp. 2451-2458. https://doi.org/10.3892/ol.2017.7627

Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma. / Kang, ChangMoo; Matsushita, Akira; Hwang, Hokyoung; Matsuda, Yoko; Kim, Hyunki; Nakamura, Yoshiharu; Lee, Woo Jung.

In: Oncology Letters, Vol. 15, No. 2, 01.02.2018, p. 2451-2458.

Research output: Contribution to journalArticle

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AU - Kang, ChangMoo

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AU - Hwang, Hokyoung

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AU - Lee, Woo Jung

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