Exploring the activated adipogenic niche: Interactions of macrophages and adipocyte progenitors

Yun Hee Lee, Robert I. Thacker, Brian Eric Hall, Raymond Kong, James G. Granneman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Adult adipose tissue contains a large supply of progenitors that can renew fat cells for homeostatic tissue maintenance and adaptive growth or regeneration in response to external challenges. However, the in vivo mechanisms that control adipocyte progenitor behavior are poorly characterized. We recently demonstrated that recruitment of adipocyte progenitors by macrophages is a central feature of adipose tissue remodeling under various adipogenic conditions. Catabolic remodeling of white adipose tissue by β3-adrenergic receptor stimulation requires anti-inflammatory M2-polarized macrophages to clear dying adipocytes and to recruit new brown adipocytes from progenitors. In this Extra Views article, we discuss in greater detail the cellular elements of adipogenic niches and report a strategy to isolate and characterize the subpopulations of macrophages and adipocyte progenitors that actively participate in adrenergic tissue remodeling. Further characterization of these subpopulations may facilitate identification of new cellular targets to improve metabolic and immune function of adipose tissue.

Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalCell Cycle
Volume13
Issue number2
DOIs
Publication statusPublished - 2014 Jan 15

Bibliographical note

Funding Information:
We thank Drs T Leff, J Wang, M Sanders, and members of CIMER for discussions. This study was supported by NIH grants (RO1DK62292 and RO1DK76629) to JGG. The Micros copy, Imaging, and Cytometry Resources Core was supported, in part, by NIH Center grant P30CA022453 to the Kar- manos Cancer Institute, Wayne State University, and the Perinatology Research Branch of the National Institutes of Child Health and Development, Wayne State University.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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