Abstract
Adult adipose tissue contains a large supply of progenitors that can renew fat cells for homeostatic tissue maintenance and adaptive growth or regeneration in response to external challenges. However, the in vivo mechanisms that control adipocyte progenitor behavior are poorly characterized. We recently demonstrated that recruitment of adipocyte progenitors by macrophages is a central feature of adipose tissue remodeling under various adipogenic conditions. Catabolic remodeling of white adipose tissue by β3-adrenergic receptor stimulation requires anti-inflammatory M2-polarized macrophages to clear dying adipocytes and to recruit new brown adipocytes from progenitors. In this Extra Views article, we discuss in greater detail the cellular elements of adipogenic niches and report a strategy to isolate and characterize the subpopulations of macrophages and adipocyte progenitors that actively participate in adrenergic tissue remodeling. Further characterization of these subpopulations may facilitate identification of new cellular targets to improve metabolic and immune function of adipose tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 184-190 |
| Number of pages | 7 |
| Journal | Cell Cycle |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Jan 15 |
Bibliographical note
Funding Information:We thank Drs T Leff, J Wang, M Sanders, and members of CIMER for discussions. This study was supported by NIH grants (RO1DK62292 and RO1DK76629) to JGG. The Micros copy, Imaging, and Cytometry Resources Core was supported, in part, by NIH Center grant P30CA022453 to the Kar- manos Cancer Institute, Wayne State University, and the Perinatology Research Branch of the National Institutes of Child Health and Development, Wayne State University.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Developmental Biology
- Cell Biology