Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study

Bo Yi Yang, Michael S. Bloom, Iana Markevych, Zhengmin (Min) Qian, Michael G. Vaughn, Lenise A. Cummings-Vaughn, Shanshan Li, Gongbo Chen, Gayan Bowatte, Jennifer L. Perret, Shyamali C. Dharmage, Joachim Heinrich, Steve Hung Lam Yim, Shao Lin, Linwei Tian, Mo Yang, Kang Kang Liu, Xiao Wen Zeng, Li Wen Hu, Yuming GuoGuang Hui Dong

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Abstract

Background: Little information exists on the lipidemic effects of air pollution, particularly in developing countries. We aimed to investigate the associations of long-term exposure to ambient air pollutants with lipid levels and dyslipidemias in China. Methods: In 2009, a total of 15,477 participants aged 18–74 years were recruited from the 33 Communities Chinese Health Study conducted in three Northeastern China cities. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured in participants’ blood specimens. Three year (2006–08) average air pollution concentrations were assessed using data from 33 communities (particles with diameters ≤1.0 μm (PM 1 ) and ≤2.5 μm (PM 2.5 ) were predicted using a spatial statistical model) or 11 air monitoring stations (particles with diameters ≤10 μm (PM 10 ), sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), and ozone (O 3 )). Associations were evaluated by two-level logistic and generalized linear regression models. Results: We detected many significant associations between exposure to air pollutants (especially for PM 1 and PM 2.5 ) and blood lipid levels. Most of the associations suggested deleterious effects on blood lipid markers (e.g., a 10 μg/m 3 increase in PM 1 was associated with 1.6% (95% confidence interval (CI): 1.1, 2.0), 2.9% (95% CI: −3.3, 9.3), and 3.2% (95% CI: 2.6, 3.9) higher levels of TC, TG, and LDL-C, respectively, but 1.4% (95% CI: −1.8, −0.9) lower HDL-C levels), although beneficial associations were found for O 3 . In analysis with dyslipidemias, all the observed associations suggested deleterious lipidemic effects of air pollutants, and no significant beneficial association was observed for O 3 . Stratified analyses showed that the associations were stronger in overweight or obese participants; sex and age modified the associations, but the pattern of effects was mixed. Conclusions: Long-term ambient air pollution was associated with both altered lipid profiles and dyslipidemias, especially among overweight or obese participants.

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalEnvironment International
Volume119
DOIs
Publication statusPublished - 2018 Oct

All Science Journal Classification (ASJC) codes

  • Environmental Science(all)

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    Yang, B. Y., Bloom, M. S., Markevych, I., Qian, Z. M., Vaughn, M. G., Cummings-Vaughn, L. A., Li, S., Chen, G., Bowatte, G., Perret, J. L., Dharmage, S. C., Heinrich, J., Yim, S. H. L., Lin, S., Tian, L., Yang, M., Liu, K. K., Zeng, X. W., Hu, L. W., ... Dong, G. H. (2018). Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study. Environment International, 119, 485-492. https://doi.org/10.1016/j.envint.2018.07.016