Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case-control study

Sun Min Kim, Byoung Kyu Cho, Min Jueng Kang, Errol R. Norwitz, Seung Mi Lee, Joonho Lee, Chan Wook Park, Byoung Jae Kim, Jong Kwan Jun, Joong Shin Park, Eugene C. Yi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Defective deep placentation, involving abnormal transformation of the spiral arteries in the junctional zone of the myometrium, is known to cause significant obstetric complications, such as preeclampsia (PE), fetal growth restriction, and placental infarction leading to fetal death. Serological biomarkers to predict and diagnose PE would help antenatal care and reduce obstetric complications. To discover candidate PE biomarkers, we first performed global proteomic profiling of three pairs of plasma samples obtained from pregnant women in the early second trimester, who subsequently developed PE, and controls to identify candidate proteins that were abundant in the patients. We further evaluated the changes in the expression of PE-representing proteins in stored plasma samples of a cohort that subsequently developed PE and their matched controls by MRM-MS analysis. We identified that both complement C1s subcomponent (C1S) and protein AMBP were elevated in the plasma samples of the PE cohort before the manifestation of clinical disease. We propose that these proteins may be involved in the remodeling process of the spiral arteries even before PE manifestation. These proteins can serve as potential plasma biomarkers to predict the pregnant women having an increased risk of developing PE.

Original languageEnglish
Pages (from-to)1581-1589
Number of pages9
JournalProteomics
Volume16
Issue number10
DOIs
Publication statusPublished - 2016 May 1

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Pre-Eclampsia
Case-Control Studies
Mothers
Plasmas
Biomarkers
Obstetrics
Proteins
Complement C1s
Pregnant Women
Arteries
Placentation
Fetal Death
Prenatal Care
Myometrium
Second Pregnancy Trimester
Fetal Development
Proteomics
Infarction

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Kim, Sun Min ; Cho, Byoung Kyu ; Kang, Min Jueng ; Norwitz, Errol R. ; Lee, Seung Mi ; Lee, Joonho ; Park, Chan Wook ; Kim, Byoung Jae ; Jun, Jong Kwan ; Park, Joong Shin ; Yi, Eugene C. / Expression changes of proteins associated with the development of preeclampsia in maternal plasma : A case-control study. In: Proteomics. 2016 ; Vol. 16, No. 10. pp. 1581-1589.
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Kim, SM, Cho, BK, Kang, MJ, Norwitz, ER, Lee, SM, Lee, J, Park, CW, Kim, BJ, Jun, JK, Park, JS & Yi, EC 2016, 'Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case-control study', Proteomics, vol. 16, no. 10, pp. 1581-1589. https://doi.org/10.1002/pmic.201500381

Expression changes of proteins associated with the development of preeclampsia in maternal plasma : A case-control study. / Kim, Sun Min; Cho, Byoung Kyu; Kang, Min Jueng; Norwitz, Errol R.; Lee, Seung Mi; Lee, Joonho; Park, Chan Wook; Kim, Byoung Jae; Jun, Jong Kwan; Park, Joong Shin; Yi, Eugene C.

In: Proteomics, Vol. 16, No. 10, 01.05.2016, p. 1581-1589.

Research output: Contribution to journalArticle

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AU - Kim, Sun Min

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AU - Lee, Seung Mi

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AU - Park, Chan Wook

AU - Kim, Byoung Jae

AU - Jun, Jong Kwan

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AU - Yi, Eugene C.

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