Expression of Biliary Antigen and Its Clinical Significance in Hepatocellular Carcinoma

Dong Sup Yoon, Joon Jeong, Young Nyun Park, Kyung Sik Kim, Sung Won Kwon, Hoon Sang Chi, Chanil Park, Byong Ro Kim

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Abstract

In order to classify the hepatocellular carcinomas (HCCs) which had diverse clinicopathologic characteristics, we divided HCCs into two groups according to the expression of biliary antigen on the basis of the hypothesis that the hepatocyte and biliary epithelial cell originate from the same precursor cell, and then we investigated the clinical and pathologic characteristics in the two groups. Forty HCC cases with no preoperative treatment and at least two-year follow-up data were selected among 202 cases of HCC files from 1991 to 1995. Expression of biliary antigen (AE1, cytokeratin 19), p53, AFP, and Ki-67 in the tumor tissue were assessed by immunohistochemistry. Positive cytokeratin 19 was noted in one case (2.5%); AE1 was detected in 40% of patients; p53 was ovetexpressed in 20% of patients; and AFP was detected in 45% of patients. No statistical difference between the biliary antigen positive group (16 cases) and the negative group (24 cases) were noted in terms of mean age, sex, presurgical serum AFP level, Child class, and tumor size. HBsAg positive rate was 66.7% for the biliary antigen ( - ) group and 93.8% for the biliary antigen ( + ) group with a statistically significant difference (p=0.048). The number of cases for Edmonson-Steiner grade I/II and III/IV were 15 and 9 in the biliary antigen ( - ) group, and 4 and 12 in the biliary antigen ( + ) group, respectively, with a statistically significant difference (p = 0.024). The 1, 3 and 5-year disease-free survival rates were 69.7, 40.9 and 40.9% for the biliary antigen ( - ) group and 73.7, 39.1, 39.1% for the biliary antigen ( + ) group with no statistically significant difference. The 1, 3 and 5-year overall survival rates were 91.7, 73.8, 66.4% for the biliary antigen ( - ) group and 68.8, 34.4, 34.4% for the biliary antigen ( + ) group, with a significantly greater overall survival rate for the biliary antigen negative group (p=0.045). Poor histopathological differentiation, a high HBsAg positive rate and poor overall survival rate were noted in the biliary antigen positive group and the differences were statistically significant. In conclusion, HCCs with positive biliary antigen, which originates from more primitive cells, is suggested to be more aggressive than HCCs with negative biliary antigen.

Original languageEnglish
Pages (from-to)472-477
Number of pages6
JournalYonsei medical journal
Volume40
Issue number5
DOIs
Publication statusPublished - 1999 Jan 1

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Hepatocellular Carcinoma
Antigens
Survival Rate
Keratin-19
Hepatitis B Surface Antigens
Disease-Free Survival
Hepatocytes
Neoplasms
Epithelial Cells
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoon, Dong Sup ; Jeong, Joon ; Park, Young Nyun ; Kim, Kyung Sik ; Kwon, Sung Won ; Chi, Hoon Sang ; Park, Chanil ; Kim, Byong Ro. / Expression of Biliary Antigen and Its Clinical Significance in Hepatocellular Carcinoma. In: Yonsei medical journal. 1999 ; Vol. 40, No. 5. pp. 472-477.
@article{043682cc80294f6c9e9b0986c56b550b,
title = "Expression of Biliary Antigen and Its Clinical Significance in Hepatocellular Carcinoma",
abstract = "In order to classify the hepatocellular carcinomas (HCCs) which had diverse clinicopathologic characteristics, we divided HCCs into two groups according to the expression of biliary antigen on the basis of the hypothesis that the hepatocyte and biliary epithelial cell originate from the same precursor cell, and then we investigated the clinical and pathologic characteristics in the two groups. Forty HCC cases with no preoperative treatment and at least two-year follow-up data were selected among 202 cases of HCC files from 1991 to 1995. Expression of biliary antigen (AE1, cytokeratin 19), p53, AFP, and Ki-67 in the tumor tissue were assessed by immunohistochemistry. Positive cytokeratin 19 was noted in one case (2.5{\%}); AE1 was detected in 40{\%} of patients; p53 was ovetexpressed in 20{\%} of patients; and AFP was detected in 45{\%} of patients. No statistical difference between the biliary antigen positive group (16 cases) and the negative group (24 cases) were noted in terms of mean age, sex, presurgical serum AFP level, Child class, and tumor size. HBsAg positive rate was 66.7{\%} for the biliary antigen ( - ) group and 93.8{\%} for the biliary antigen ( + ) group with a statistically significant difference (p=0.048). The number of cases for Edmonson-Steiner grade I/II and III/IV were 15 and 9 in the biliary antigen ( - ) group, and 4 and 12 in the biliary antigen ( + ) group, respectively, with a statistically significant difference (p = 0.024). The 1, 3 and 5-year disease-free survival rates were 69.7, 40.9 and 40.9{\%} for the biliary antigen ( - ) group and 73.7, 39.1, 39.1{\%} for the biliary antigen ( + ) group with no statistically significant difference. The 1, 3 and 5-year overall survival rates were 91.7, 73.8, 66.4{\%} for the biliary antigen ( - ) group and 68.8, 34.4, 34.4{\%} for the biliary antigen ( + ) group, with a significantly greater overall survival rate for the biliary antigen negative group (p=0.045). Poor histopathological differentiation, a high HBsAg positive rate and poor overall survival rate were noted in the biliary antigen positive group and the differences were statistically significant. In conclusion, HCCs with positive biliary antigen, which originates from more primitive cells, is suggested to be more aggressive than HCCs with negative biliary antigen.",
author = "Yoon, {Dong Sup} and Joon Jeong and Park, {Young Nyun} and Kim, {Kyung Sik} and Kwon, {Sung Won} and Chi, {Hoon Sang} and Chanil Park and Kim, {Byong Ro}",
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Yoon, DS, Jeong, J, Park, YN, Kim, KS, Kwon, SW, Chi, HS, Park, C & Kim, BR 1999, 'Expression of Biliary Antigen and Its Clinical Significance in Hepatocellular Carcinoma', Yonsei medical journal, vol. 40, no. 5, pp. 472-477. https://doi.org/10.3349/ymj.1999.40.5.472

Expression of Biliary Antigen and Its Clinical Significance in Hepatocellular Carcinoma. / Yoon, Dong Sup; Jeong, Joon; Park, Young Nyun; Kim, Kyung Sik; Kwon, Sung Won; Chi, Hoon Sang; Park, Chanil; Kim, Byong Ro.

In: Yonsei medical journal, Vol. 40, No. 5, 01.01.1999, p. 472-477.

Research output: Contribution to journalArticle

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AU - Yoon, Dong Sup

AU - Jeong, Joon

AU - Park, Young Nyun

AU - Kim, Kyung Sik

AU - Kwon, Sung Won

AU - Chi, Hoon Sang

AU - Park, Chanil

AU - Kim, Byong Ro

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Y1 - 1999/1/1

N2 - In order to classify the hepatocellular carcinomas (HCCs) which had diverse clinicopathologic characteristics, we divided HCCs into two groups according to the expression of biliary antigen on the basis of the hypothesis that the hepatocyte and biliary epithelial cell originate from the same precursor cell, and then we investigated the clinical and pathologic characteristics in the two groups. Forty HCC cases with no preoperative treatment and at least two-year follow-up data were selected among 202 cases of HCC files from 1991 to 1995. Expression of biliary antigen (AE1, cytokeratin 19), p53, AFP, and Ki-67 in the tumor tissue were assessed by immunohistochemistry. Positive cytokeratin 19 was noted in one case (2.5%); AE1 was detected in 40% of patients; p53 was ovetexpressed in 20% of patients; and AFP was detected in 45% of patients. No statistical difference between the biliary antigen positive group (16 cases) and the negative group (24 cases) were noted in terms of mean age, sex, presurgical serum AFP level, Child class, and tumor size. HBsAg positive rate was 66.7% for the biliary antigen ( - ) group and 93.8% for the biliary antigen ( + ) group with a statistically significant difference (p=0.048). The number of cases for Edmonson-Steiner grade I/II and III/IV were 15 and 9 in the biliary antigen ( - ) group, and 4 and 12 in the biliary antigen ( + ) group, respectively, with a statistically significant difference (p = 0.024). The 1, 3 and 5-year disease-free survival rates were 69.7, 40.9 and 40.9% for the biliary antigen ( - ) group and 73.7, 39.1, 39.1% for the biliary antigen ( + ) group with no statistically significant difference. The 1, 3 and 5-year overall survival rates were 91.7, 73.8, 66.4% for the biliary antigen ( - ) group and 68.8, 34.4, 34.4% for the biliary antigen ( + ) group, with a significantly greater overall survival rate for the biliary antigen negative group (p=0.045). Poor histopathological differentiation, a high HBsAg positive rate and poor overall survival rate were noted in the biliary antigen positive group and the differences were statistically significant. In conclusion, HCCs with positive biliary antigen, which originates from more primitive cells, is suggested to be more aggressive than HCCs with negative biliary antigen.

AB - In order to classify the hepatocellular carcinomas (HCCs) which had diverse clinicopathologic characteristics, we divided HCCs into two groups according to the expression of biliary antigen on the basis of the hypothesis that the hepatocyte and biliary epithelial cell originate from the same precursor cell, and then we investigated the clinical and pathologic characteristics in the two groups. Forty HCC cases with no preoperative treatment and at least two-year follow-up data were selected among 202 cases of HCC files from 1991 to 1995. Expression of biliary antigen (AE1, cytokeratin 19), p53, AFP, and Ki-67 in the tumor tissue were assessed by immunohistochemistry. Positive cytokeratin 19 was noted in one case (2.5%); AE1 was detected in 40% of patients; p53 was ovetexpressed in 20% of patients; and AFP was detected in 45% of patients. No statistical difference between the biliary antigen positive group (16 cases) and the negative group (24 cases) were noted in terms of mean age, sex, presurgical serum AFP level, Child class, and tumor size. HBsAg positive rate was 66.7% for the biliary antigen ( - ) group and 93.8% for the biliary antigen ( + ) group with a statistically significant difference (p=0.048). The number of cases for Edmonson-Steiner grade I/II and III/IV were 15 and 9 in the biliary antigen ( - ) group, and 4 and 12 in the biliary antigen ( + ) group, respectively, with a statistically significant difference (p = 0.024). The 1, 3 and 5-year disease-free survival rates were 69.7, 40.9 and 40.9% for the biliary antigen ( - ) group and 73.7, 39.1, 39.1% for the biliary antigen ( + ) group with no statistically significant difference. The 1, 3 and 5-year overall survival rates were 91.7, 73.8, 66.4% for the biliary antigen ( - ) group and 68.8, 34.4, 34.4% for the biliary antigen ( + ) group, with a significantly greater overall survival rate for the biliary antigen negative group (p=0.045). Poor histopathological differentiation, a high HBsAg positive rate and poor overall survival rate were noted in the biliary antigen positive group and the differences were statistically significant. In conclusion, HCCs with positive biliary antigen, which originates from more primitive cells, is suggested to be more aggressive than HCCs with negative biliary antigen.

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