Expression of cyclin E and p27(KIP1) in cervical carcinoma

YoungTae Kim, Eun Kyoung Choi, Namhoon Cho, Jae Hung Ko, Woo Ick Yang, Jae Wook Kim, Seung Ho Lee

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Carcinogenesis is characterized by deregulation of the cell cycle. Although p53 is still the most important cell-cycle regulator in human malignancies, there is an increased body of evidence indicating that the aberrant expression of cyclins and cyclin-dependent kinase (CDK) inhibitors is considered as one of the most important events in malignant transformation of various human cancers. Among these cell-cycle regulators, the role of cyclin E and p27(KIP1) in the tumorigenesis of the uterine cervix has been poorly defined. Using formalin-fixed, paraffin-embedded cervical tissues, we investigated the expression of cyclin E and p27(KIP1) by immunohistochemistry, and human papillomavirus (HPV) types 16 and 18 by nested polymerase chain reaction (PCR) in 22 control cases, 23 cases with cervical intraepithelial neoplasia (CIN), and 45 patients with invasive cervical carcinoma (ICC). The p27 index (P27I) was significantly lower in patients with ICC and CIN compared to those with a normal cervix. Patients with either invasive cancer or CIN were found to have a significantly higher cyclin E index (CEI) than the controls (P<0.05). Our results were consistent with the concept that the deregulated expression of cyclin E and p27(KIP1) may play an important role in the neoplastic transformation of cervical carcinoma. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalCancer Letters
Volume153
Issue number1-2
DOIs
Publication statusPublished - 2000 May 29

Fingerprint

Cyclin E
Cervical Intraepithelial Neoplasia
Carcinoma
Cell Cycle
Cervix Uteri
Carcinogenesis
Human papillomavirus 18
Neoplasms
Cyclins
Human papillomavirus 16
Cyclin-Dependent Kinases
Paraffin
Formaldehyde
Immunohistochemistry
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kim, Y., Kyoung Choi, E., Cho, N., Hung Ko, J., Ick Yang, W., Wook Kim, J., & Ho Lee, S. (2000). Expression of cyclin E and p27(KIP1) in cervical carcinoma. Cancer Letters, 153(1-2), 41-50. https://doi.org/10.1016/S0304-3835(00)00345-1
Kim, YoungTae ; Kyoung Choi, Eun ; Cho, Namhoon ; Hung Ko, Jae ; Ick Yang, Woo ; Wook Kim, Jae ; Ho Lee, Seung. / Expression of cyclin E and p27(KIP1) in cervical carcinoma. In: Cancer Letters. 2000 ; Vol. 153, No. 1-2. pp. 41-50.
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Kim, Y, Kyoung Choi, E, Cho, N, Hung Ko, J, Ick Yang, W, Wook Kim, J & Ho Lee, S 2000, 'Expression of cyclin E and p27(KIP1) in cervical carcinoma', Cancer Letters, vol. 153, no. 1-2, pp. 41-50. https://doi.org/10.1016/S0304-3835(00)00345-1

Expression of cyclin E and p27(KIP1) in cervical carcinoma. / Kim, YoungTae; Kyoung Choi, Eun; Cho, Namhoon; Hung Ko, Jae; Ick Yang, Woo; Wook Kim, Jae; Ho Lee, Seung.

In: Cancer Letters, Vol. 153, No. 1-2, 29.05.2000, p. 41-50.

Research output: Contribution to journalArticle

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Kim Y, Kyoung Choi E, Cho N, Hung Ko J, Ick Yang W, Wook Kim J et al. Expression of cyclin E and p27(KIP1) in cervical carcinoma. Cancer Letters. 2000 May 29;153(1-2):41-50. https://doi.org/10.1016/S0304-3835(00)00345-1