Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial carcinoma

Young Tae Kim, Eun Kyung Choi, Jae Wook Kim, Dong Kyu Kim, Sung Hoon Kim, Woo Ick Yang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Loss of the cell adhesion molecule E-cadherin is suggested to promote tumor invasion and distant metastasis in tumor development. Recently, it has been proposed that E-cadherin function requires its linkage to the cytoskeleton through catenins. We evaluated the expression of E-cadherin and α-, β-, and γ-catenins in tissues of human endometrial carcinoma, analyzed the patterns of cell adhesion molecules' expression in endometrial carcinoma and investigated the relationship between the statuses of cell adhesion molecules and various clinicopathological factors. This study investigated the immunohistochemical expression of E-cadherin and a-, β-, and γ-catenins in 33 paraffin embedded formalin fixed tissues of endometrial carcinomas. Aberrant E-cadherin, and a-, β-, and γ-catenin expression was observed in 33.3 (11 of 33), 27.3 (9 of 33), 18.2 (6 of 33), and 51.5 (17 of 33) % of the specimens, respectively. Statistically significant correlation was found between aberrant expression of E-cadherin and lymph node metastasis and cell types other than endometrioid adenocarcinoma. Aberrant pattern of γ-catenin expression was also correlated with deep myometrial invasion. However, α-, and β-catenin expression was not correlated with any clinico-pathological parameters. Using the Kaplan-Meier method and log-rank comparison test, abnormal expression of E-cadherin was correlated closely with poor survival (p<0.05), but cases with loss of both E-cadherin and catenin expression predicted even poorer survival than cases with only one or no aberrant expression in E-cadherin and catenins. We revealed aberrant expression of these cell adhesion molecules among patients with endometrial carcinoma. Aberrant expression of E-cadherin was correlated with lymph node metastasis and cell types other than endometrioid adenocarcinoma, while aberrant expression of γ-catenin was related with deep myometrial invasion. The expression of E-cadherin might be a possible prognostic factor for endometrial cancer while the expression of catenins may help predict patient's survival.

Original languageEnglish
Pages (from-to)701-711
Number of pages11
JournalYonsei medical journal
Volume43
Issue number6
DOIs
Publication statusPublished - 2002 Dec

Fingerprint

Catenins
Cadherins
Endometrial Neoplasms
Cell Adhesion Molecules
Endometrioid Carcinoma
Neoplasm Metastasis
Survival
Lymph Nodes
Cytoskeleton
Paraffin
Formaldehyde
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Young Tae ; Choi, Eun Kyung ; Kim, Jae Wook ; Kim, Dong Kyu ; Kim, Sung Hoon ; Yang, Woo Ick. / Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial carcinoma. In: Yonsei medical journal. 2002 ; Vol. 43, No. 6. pp. 701-711.
@article{be2fe3d6f70e4ec69c30dde29a012a22,
title = "Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial carcinoma",
abstract = "Loss of the cell adhesion molecule E-cadherin is suggested to promote tumor invasion and distant metastasis in tumor development. Recently, it has been proposed that E-cadherin function requires its linkage to the cytoskeleton through catenins. We evaluated the expression of E-cadherin and α-, β-, and γ-catenins in tissues of human endometrial carcinoma, analyzed the patterns of cell adhesion molecules' expression in endometrial carcinoma and investigated the relationship between the statuses of cell adhesion molecules and various clinicopathological factors. This study investigated the immunohistochemical expression of E-cadherin and a-, β-, and γ-catenins in 33 paraffin embedded formalin fixed tissues of endometrial carcinomas. Aberrant E-cadherin, and a-, β-, and γ-catenin expression was observed in 33.3 (11 of 33), 27.3 (9 of 33), 18.2 (6 of 33), and 51.5 (17 of 33) {\%} of the specimens, respectively. Statistically significant correlation was found between aberrant expression of E-cadherin and lymph node metastasis and cell types other than endometrioid adenocarcinoma. Aberrant pattern of γ-catenin expression was also correlated with deep myometrial invasion. However, α-, and β-catenin expression was not correlated with any clinico-pathological parameters. Using the Kaplan-Meier method and log-rank comparison test, abnormal expression of E-cadherin was correlated closely with poor survival (p<0.05), but cases with loss of both E-cadherin and catenin expression predicted even poorer survival than cases with only one or no aberrant expression in E-cadherin and catenins. We revealed aberrant expression of these cell adhesion molecules among patients with endometrial carcinoma. Aberrant expression of E-cadherin was correlated with lymph node metastasis and cell types other than endometrioid adenocarcinoma, while aberrant expression of γ-catenin was related with deep myometrial invasion. The expression of E-cadherin might be a possible prognostic factor for endometrial cancer while the expression of catenins may help predict patient's survival.",
author = "Kim, {Young Tae} and Choi, {Eun Kyung} and Kim, {Jae Wook} and Kim, {Dong Kyu} and Kim, {Sung Hoon} and Yang, {Woo Ick}",
year = "2002",
month = "12",
doi = "10.3349/ymj.2002.43.6.701",
language = "English",
volume = "43",
pages = "701--711",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "6",

}

Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial carcinoma. / Kim, Young Tae; Choi, Eun Kyung; Kim, Jae Wook; Kim, Dong Kyu; Kim, Sung Hoon; Yang, Woo Ick.

In: Yonsei medical journal, Vol. 43, No. 6, 12.2002, p. 701-711.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial carcinoma

AU - Kim, Young Tae

AU - Choi, Eun Kyung

AU - Kim, Jae Wook

AU - Kim, Dong Kyu

AU - Kim, Sung Hoon

AU - Yang, Woo Ick

PY - 2002/12

Y1 - 2002/12

N2 - Loss of the cell adhesion molecule E-cadherin is suggested to promote tumor invasion and distant metastasis in tumor development. Recently, it has been proposed that E-cadherin function requires its linkage to the cytoskeleton through catenins. We evaluated the expression of E-cadherin and α-, β-, and γ-catenins in tissues of human endometrial carcinoma, analyzed the patterns of cell adhesion molecules' expression in endometrial carcinoma and investigated the relationship between the statuses of cell adhesion molecules and various clinicopathological factors. This study investigated the immunohistochemical expression of E-cadherin and a-, β-, and γ-catenins in 33 paraffin embedded formalin fixed tissues of endometrial carcinomas. Aberrant E-cadherin, and a-, β-, and γ-catenin expression was observed in 33.3 (11 of 33), 27.3 (9 of 33), 18.2 (6 of 33), and 51.5 (17 of 33) % of the specimens, respectively. Statistically significant correlation was found between aberrant expression of E-cadherin and lymph node metastasis and cell types other than endometrioid adenocarcinoma. Aberrant pattern of γ-catenin expression was also correlated with deep myometrial invasion. However, α-, and β-catenin expression was not correlated with any clinico-pathological parameters. Using the Kaplan-Meier method and log-rank comparison test, abnormal expression of E-cadherin was correlated closely with poor survival (p<0.05), but cases with loss of both E-cadherin and catenin expression predicted even poorer survival than cases with only one or no aberrant expression in E-cadherin and catenins. We revealed aberrant expression of these cell adhesion molecules among patients with endometrial carcinoma. Aberrant expression of E-cadherin was correlated with lymph node metastasis and cell types other than endometrioid adenocarcinoma, while aberrant expression of γ-catenin was related with deep myometrial invasion. The expression of E-cadherin might be a possible prognostic factor for endometrial cancer while the expression of catenins may help predict patient's survival.

AB - Loss of the cell adhesion molecule E-cadherin is suggested to promote tumor invasion and distant metastasis in tumor development. Recently, it has been proposed that E-cadherin function requires its linkage to the cytoskeleton through catenins. We evaluated the expression of E-cadherin and α-, β-, and γ-catenins in tissues of human endometrial carcinoma, analyzed the patterns of cell adhesion molecules' expression in endometrial carcinoma and investigated the relationship between the statuses of cell adhesion molecules and various clinicopathological factors. This study investigated the immunohistochemical expression of E-cadherin and a-, β-, and γ-catenins in 33 paraffin embedded formalin fixed tissues of endometrial carcinomas. Aberrant E-cadherin, and a-, β-, and γ-catenin expression was observed in 33.3 (11 of 33), 27.3 (9 of 33), 18.2 (6 of 33), and 51.5 (17 of 33) % of the specimens, respectively. Statistically significant correlation was found between aberrant expression of E-cadherin and lymph node metastasis and cell types other than endometrioid adenocarcinoma. Aberrant pattern of γ-catenin expression was also correlated with deep myometrial invasion. However, α-, and β-catenin expression was not correlated with any clinico-pathological parameters. Using the Kaplan-Meier method and log-rank comparison test, abnormal expression of E-cadherin was correlated closely with poor survival (p<0.05), but cases with loss of both E-cadherin and catenin expression predicted even poorer survival than cases with only one or no aberrant expression in E-cadherin and catenins. We revealed aberrant expression of these cell adhesion molecules among patients with endometrial carcinoma. Aberrant expression of E-cadherin was correlated with lymph node metastasis and cell types other than endometrioid adenocarcinoma, while aberrant expression of γ-catenin was related with deep myometrial invasion. The expression of E-cadherin might be a possible prognostic factor for endometrial cancer while the expression of catenins may help predict patient's survival.

UR - http://www.scopus.com/inward/record.url?scp=0036957026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036957026&partnerID=8YFLogxK

U2 - 10.3349/ymj.2002.43.6.701

DO - 10.3349/ymj.2002.43.6.701

M3 - Article

C2 - 12497652

AN - SCOPUS:0036957026

VL - 43

SP - 701

EP - 711

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 6

ER -