Expression of Eosinophil Chemotactic Factors in Stomach Cancer

Soon Won Hong, Meeyon Cho, Chanil Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have occasionally experienced eosinophilic abscess of the liver in patients with gastric carcinoma, suggesting that some eosinophil mobilizing (chemotactic and proliferative) factors might be produced by carcinoma cells. The aim of this study was to determine whether or not gastric carcinoma expresses the well-known eosinophil chemotactic factors (ECFs) and whether or not the expression is related to the histologic subtypes. Seventeen consecutive surgically removed tumor-bearing stomachs were collected: 7 signet ring cell type, 7 poorly differentiated tubular adenocarcinoma, and 3 moderately differentiated tubular adenocarcinoma. Hematoxylin-eosin stained sections were re-evaluated for eosinophil and mast cell infiltration. The expressions of IL-2, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF) were examined by immunocytochemical stain. There was no available frozen tissue for IL-2 and IL-5 in one case. Gastric carcinoma expressed IL-2 in all 16 cases, IL-5 in 12 of 16 cases and GM-CSF in 10 of 17 cases. Of particular interest, 7 of 10 GM-CSF-expressing carcinomas were signet ring cell type. Even in the remaining 3 cases, most GM-CSF-positive cells were signet ring cells scattered within tubular adenocarcinoma. No correlation of ECF expression between either eosinophil/mast cell infiltration or peripheral blood eosinophilia was identified. In conclusion, most gastric carcinomas express the well-known ECFs and the expression of GM-CSF is specific for signet ring carcinoma cells.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalYonsei Medical Journal
Volume40
Issue number2
DOIs
Publication statusPublished - 1999 Jan 1

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Eosinophil Chemotactic Factors
Granulocyte-Macrophage Colony-Stimulating Factor
Stomach Neoplasms
Stomach
Carcinoma
Interleukin-5
Eosinophils
Signet Ring Cell Carcinoma
Interleukin-2
Adenocarcinoma
Mast Cells
Liver Abscess
Chemotactic Factors
Eosinophilia
Hematoxylin
Eosine Yellowish-(YS)
Coloring Agents
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hong, Soon Won ; Cho, Meeyon ; Park, Chanil. / Expression of Eosinophil Chemotactic Factors in Stomach Cancer. In: Yonsei Medical Journal. 1999 ; Vol. 40, No. 2. pp. 131-136.
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abstract = "We have occasionally experienced eosinophilic abscess of the liver in patients with gastric carcinoma, suggesting that some eosinophil mobilizing (chemotactic and proliferative) factors might be produced by carcinoma cells. The aim of this study was to determine whether or not gastric carcinoma expresses the well-known eosinophil chemotactic factors (ECFs) and whether or not the expression is related to the histologic subtypes. Seventeen consecutive surgically removed tumor-bearing stomachs were collected: 7 signet ring cell type, 7 poorly differentiated tubular adenocarcinoma, and 3 moderately differentiated tubular adenocarcinoma. Hematoxylin-eosin stained sections were re-evaluated for eosinophil and mast cell infiltration. The expressions of IL-2, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF) were examined by immunocytochemical stain. There was no available frozen tissue for IL-2 and IL-5 in one case. Gastric carcinoma expressed IL-2 in all 16 cases, IL-5 in 12 of 16 cases and GM-CSF in 10 of 17 cases. Of particular interest, 7 of 10 GM-CSF-expressing carcinomas were signet ring cell type. Even in the remaining 3 cases, most GM-CSF-positive cells were signet ring cells scattered within tubular adenocarcinoma. No correlation of ECF expression between either eosinophil/mast cell infiltration or peripheral blood eosinophilia was identified. In conclusion, most gastric carcinomas express the well-known ECFs and the expression of GM-CSF is specific for signet ring carcinoma cells.",
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Expression of Eosinophil Chemotactic Factors in Stomach Cancer. / Hong, Soon Won; Cho, Meeyon; Park, Chanil.

In: Yonsei Medical Journal, Vol. 40, No. 2, 01.01.1999, p. 131-136.

Research output: Contribution to journalArticle

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