Expression of EpCAM in adenoid cystic carcinoma

Seok Joo Lee, Kee Yang Chung, Ji Eun Kwon, SunOch Yoon, Sang Kyum Kim

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Abstract

The mutational landscape of adenoid cystic carcinoma (ACC) is currently being revealed, but further studies are needed to identify biomarkers as therapeutic targets or prognostic factors of ACC. In this study, we investigated the expression of epithelial cell adhesion molecule (EpCAM) in ACCs. We retrospectively collected 83 cases of surgically resected ACCs. Using tissue microarray, we conducted immunohistochemical staining using the anti-EpCAM antibody. EpCAM expression was analysed by intensity score and the total immunostaining score. The positivity was 97.6% (81/83 cases), regardless of the intensity score. A higher histological grade (p = 0.006) and specific tumour location (non-salivary gland origin, p = 0.02) showed a correlation with higher EpCAM intensity. Higher EpCAM expression by total immunostaining score was associated with histological grade (p = 0.004), distant metastasis (p = 0.004) and poorer prognosis (overall survival p = 0.015 and progression-free survival p = 0.033). We suggest EpCAM as a candidate prognostic marker and a putative therapeutic target in ACC. Also, ACCs arising from salivary gland and non-salivary gland sites, respectively, might display different pathophysiologies in which EpCAM could play a role.

Original languageEnglish
Pages (from-to)737-741
Number of pages5
JournalPathology
Volume50
Issue number7
DOIs
Publication statusPublished - 2018 Dec 1

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Lee, S. J., Chung, K. Y., Kwon, J. E., Yoon, S., & Kim, S. K. (2018). Expression of EpCAM in adenoid cystic carcinoma. Pathology, 50(7), 737-741. https://doi.org/10.1016/j.pathol.2018.08.013