Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol

Tin Seok Kang, Beom Jun Lee, Byeongwoo Ahn, Dae Joong Kim, Sang Yoon Nam, Young Won Yun, KiTaek Nam, Mina Choi, Hyung Sik Kim, Dong Deuk Jang, Yong Soon Lee, Ki Hwa Yang

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Abstract

The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) β. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.

Original languageEnglish
Pages (from-to)1293-1297
Number of pages5
JournalJournal of Veterinary Medical Science
Volume65
Issue number12
DOIs
Publication statusPublished - 2003 Dec 1

Fingerprint

Ethinyl Estradiol
vagina
Vagina
Estrogen Receptors
uterus
Uterus
estradiol
immatures
rats
epithelium
Epithelium
dosage
hypertrophy
Hypertrophy
estrogen receptors
estrogens
Sprague Dawley Rats
Estrogens
Weights and Measures

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Kang, Tin Seok ; Lee, Beom Jun ; Ahn, Byeongwoo ; Kim, Dae Joong ; Nam, Sang Yoon ; Yun, Young Won ; Nam, KiTaek ; Choi, Mina ; Kim, Hyung Sik ; Jang, Dong Deuk ; Lee, Yong Soon ; Yang, Ki Hwa. / Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol. In: Journal of Veterinary Medical Science. 2003 ; Vol. 65, No. 12. pp. 1293-1297.
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abstract = "The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) β. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.",
author = "Kang, {Tin Seok} and Lee, {Beom Jun} and Byeongwoo Ahn and Kim, {Dae Joong} and Nam, {Sang Yoon} and Yun, {Young Won} and KiTaek Nam and Mina Choi and Kim, {Hyung Sik} and Jang, {Dong Deuk} and Lee, {Yong Soon} and Yang, {Ki Hwa}",
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Kang, TS, Lee, BJ, Ahn, B, Kim, DJ, Nam, SY, Yun, YW, Nam, K, Choi, M, Kim, HS, Jang, DD, Lee, YS & Yang, KH 2003, 'Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol', Journal of Veterinary Medical Science, vol. 65, no. 12, pp. 1293-1297. https://doi.org/10.1292/jvms.65.1293

Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol. / Kang, Tin Seok; Lee, Beom Jun; Ahn, Byeongwoo; Kim, Dae Joong; Nam, Sang Yoon; Yun, Young Won; Nam, KiTaek; Choi, Mina; Kim, Hyung Sik; Jang, Dong Deuk; Lee, Yong Soon; Yang, Ki Hwa.

In: Journal of Veterinary Medical Science, Vol. 65, No. 12, 01.12.2003, p. 1293-1297.

Research output: Contribution to journalArticle

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T1 - Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol

AU - Kang, Tin Seok

AU - Lee, Beom Jun

AU - Ahn, Byeongwoo

AU - Kim, Dae Joong

AU - Nam, Sang Yoon

AU - Yun, Young Won

AU - Nam, KiTaek

AU - Choi, Mina

AU - Kim, Hyung Sik

AU - Jang, Dong Deuk

AU - Lee, Yong Soon

AU - Yang, Ki Hwa

PY - 2003/12/1

Y1 - 2003/12/1

N2 - The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) β. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.

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