Abstract
The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) β. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.
| Original language | English |
|---|---|
| Pages (from-to) | 1293-1297 |
| Number of pages | 5 |
| Journal | Journal of Veterinary Medical Science |
| Volume | 65 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2003 Dec 1 |
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All Science Journal Classification (ASJC) codes
- veterinary(all)
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Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol. / Kang, Tin Seok; Lee, Beom Jun; Ahn, Byeongwoo; Kim, Dae Joong; Nam, Sang Yoon; Yun, Young Won; Nam, KiTaek; Choi, Mina; Kim, Hyung Sik; Jang, Dong Deuk; Lee, Yong Soon; Yang, Ki Hwa.
In: Journal of Veterinary Medical Science, Vol. 65, No. 12, 01.12.2003, p. 1293-1297.Research output: Contribution to journal › Article
TY - JOUR
T1 - Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol
AU - Kang, Tin Seok
AU - Lee, Beom Jun
AU - Ahn, Byeongwoo
AU - Kim, Dae Joong
AU - Nam, Sang Yoon
AU - Yun, Young Won
AU - Nam, KiTaek
AU - Choi, Mina
AU - Kim, Hyung Sik
AU - Jang, Dong Deuk
AU - Lee, Yong Soon
AU - Yang, Ki Hwa
PY - 2003/12/1
Y1 - 2003/12/1
N2 - The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) β. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.
AB - The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) β. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.
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U2 - 10.1292/jvms.65.1293
DO - 10.1292/jvms.65.1293
M3 - Article
VL - 65
SP - 1293
EP - 1297
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
SN - 0916-7250
IS - 12
ER -