Expression of estrogen receptor-β in normal mammary and tumor tissues: Is it protective in breast carcinogenesis?

Byeong Woo Park, Ki Suk Kim, Min Kyu Heo, Seung Sang Ko, Soon Won Hong, Woo Ick Yang, Joo Hang Kim, Gwi Eon Kim, Kyong Sik Lee

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalBreast Cancer Research and Treatment
Volume80
Issue number1
DOIs
Publication statusPublished - 2003 Jul 1

Fingerprint

Estrogen Receptors
Carcinogenesis
Breast
Breast Neoplasms
Messenger RNA
Lymph Nodes
Progesterone Receptors
In Situ Hybridization
Recurrence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Park, Byeong Woo ; Kim, Ki Suk ; Heo, Min Kyu ; Ko, Seung Sang ; Hong, Soon Won ; Yang, Woo Ick ; Kim, Joo Hang ; Kim, Gwi Eon ; Lee, Kyong Sik. / Expression of estrogen receptor-β in normal mammary and tumor tissues : Is it protective in breast carcinogenesis?. In: Breast Cancer Research and Treatment. 2003 ; Vol. 80, No. 1. pp. 79-85.
@article{6a2ad9d894a347918e30a9730fd4853e,
title = "Expression of estrogen receptor-β in normal mammary and tumor tissues: Is it protective in breast carcinogenesis?",
abstract = "Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.",
author = "Park, {Byeong Woo} and Kim, {Ki Suk} and Heo, {Min Kyu} and Ko, {Seung Sang} and Hong, {Soon Won} and Yang, {Woo Ick} and Kim, {Joo Hang} and Kim, {Gwi Eon} and Lee, {Kyong Sik}",
year = "2003",
month = "7",
day = "1",
doi = "10.1023/A:1024406223619",
language = "English",
volume = "80",
pages = "79--85",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "1",

}

Expression of estrogen receptor-β in normal mammary and tumor tissues : Is it protective in breast carcinogenesis? / Park, Byeong Woo; Kim, Ki Suk; Heo, Min Kyu; Ko, Seung Sang; Hong, Soon Won; Yang, Woo Ick; Kim, Joo Hang; Kim, Gwi Eon; Lee, Kyong Sik.

In: Breast Cancer Research and Treatment, Vol. 80, No. 1, 01.07.2003, p. 79-85.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Expression of estrogen receptor-β in normal mammary and tumor tissues

T2 - Is it protective in breast carcinogenesis?

AU - Park, Byeong Woo

AU - Kim, Ki Suk

AU - Heo, Min Kyu

AU - Ko, Seung Sang

AU - Hong, Soon Won

AU - Yang, Woo Ick

AU - Kim, Joo Hang

AU - Kim, Gwi Eon

AU - Lee, Kyong Sik

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.

AB - Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.

UR - http://www.scopus.com/inward/record.url?scp=0038160964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038160964&partnerID=8YFLogxK

U2 - 10.1023/A:1024406223619

DO - 10.1023/A:1024406223619

M3 - Article

C2 - 12889601

AN - SCOPUS:0038160964

VL - 80

SP - 79

EP - 85

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 1

ER -