Expression of estrogen receptor-β in normal mammary and tumor tissues: Is it protective in breast carcinogenesis?

Byeong Woo Park, Ki Suk Kim, Min Kyu Heo, Seung Sang Ko, Soon Won Hong, Woo Ick Yang, Joo Hang Kim, Gwi Eon Kim, Kyong Sik Lee

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalBreast Cancer Research and Treatment
Volume80
Issue number1
DOIs
Publication statusPublished - 2003 Jul 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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