The involvement of estrogen receptor beta (ERβ) in prostate carcinogenesis has been hypothesized. Several reports have shown that ERβ expression was decreased when prostate cells undergo neoplastic transformation, suggesting that it could play a tumor-suppressor role. By restoring ERβ expression in prostatic carcinoma cells by adenoviral delivery, we aimed to test this hypothesis. We observed that ERβ strongly inhibited the invasiveness and the growth of these cells. In addition, ERβ cells were undergoing apoptosis, as shown by quantification of Bax, poly(ADP-ribose) polymerase and caspase-3 expression. Our data suggest that ERβ acts as a tumor-suppressor by its anti-proliferative, anti-invasive and pro-apoptotic properties.
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology
- Cell Biology