Expression of GABAA receptor β2/3 subunits in the rat major pelvic ganglion

Jung Cheol Park, Dae Yong Song, Jin Suk Lee, Indeok Kong, Seong Woo Jeong, Bong Hee Lee, Ho Suck Kang, Byung Pil Cho

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Abstract

Several pharmacological and physiological studies have suggested that GABAA receptors (GABAA Rs) may exist in the rat major pelvic ganglion (MPG), a large coalescent pelvic ganglion that contains both sympathetic and parasympathetic components which innervates pelvic organs. However, the presence of GABAA R in the MPG has never been demonstrated directly by morphological studies. In the present study, we used immunohistochemistry to demonstrate the existence of GABAA R β2/3 subunits for the first time in the rat MPG. We also analyzed the neurochemical properties of MPG neurons expressing GABAA R β2/3 subunits. GABAA R β2/3-immunoreactive (-IR) neurons occupied 27.4 ± 7.0% of the whole neuronal population, and many of these (77.6%) were co-localized with tyrosine hydroxylase (TH). Likewise, most (86.5%) of TH-IR neurons were GABAA R β2/3-positive. GABAA R β2/3 subunits were also expressed in a few VIP- or NOS-IR neurons, the cholinergic or non-adrenergic, non-cholinergic (NANC) neurons. These results suggest that GABAA Rs are involved in the modulation of most sympathetic, noradrenergic neurons and also a subset of VIP and NOS neurons of the rat MPG.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalNeuroscience Letters
Volume403
Issue number1-2
DOIs
Publication statusPublished - 2006 Jul 31

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Park, J. C., Song, D. Y., Lee, J. S., Kong, I., Jeong, S. W., Lee, B. H., Kang, H. S., & Cho, B. P. (2006). Expression of GABAA receptor β2/3 subunits in the rat major pelvic ganglion. Neuroscience Letters, 403(1-2), 35-39. https://doi.org/10.1016/j.neulet.2006.04.051