Expression of GABAA receptor β2/3 subunits in the rat major pelvic ganglion

Jung Cheol Park, Dae Yong Song, Jin Suk Lee, Indeok Kong, Seong Woo Jeong, Bong Hee Lee, Ho Suck Kang, Byung Pil Cho

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Several pharmacological and physiological studies have suggested that GABAA receptors (GABAA Rs) may exist in the rat major pelvic ganglion (MPG), a large coalescent pelvic ganglion that contains both sympathetic and parasympathetic components which innervates pelvic organs. However, the presence of GABAA R in the MPG has never been demonstrated directly by morphological studies. In the present study, we used immunohistochemistry to demonstrate the existence of GABAA R β2/3 subunits for the first time in the rat MPG. We also analyzed the neurochemical properties of MPG neurons expressing GABAA R β2/3 subunits. GABAA R β2/3-immunoreactive (-IR) neurons occupied 27.4 ± 7.0% of the whole neuronal population, and many of these (77.6%) were co-localized with tyrosine hydroxylase (TH). Likewise, most (86.5%) of TH-IR neurons were GABAA R β2/3-positive. GABAA R β2/3 subunits were also expressed in a few VIP- or NOS-IR neurons, the cholinergic or non-adrenergic, non-cholinergic (NANC) neurons. These results suggest that GABAA Rs are involved in the modulation of most sympathetic, noradrenergic neurons and also a subset of VIP and NOS neurons of the rat MPG.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalNeuroscience Letters
Volume403
Issue number1-2
DOIs
Publication statusPublished - 2006 Jul 31

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GABA-A Receptors
Ganglia
Neurons
Tyrosine 3-Monooxygenase
Adrenergic Neurons
Cholinergic Neurons
Immunohistochemistry
Pharmacology
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Park, J. C., Song, D. Y., Lee, J. S., Kong, I., Jeong, S. W., Lee, B. H., ... Cho, B. P. (2006). Expression of GABAA receptor β2/3 subunits in the rat major pelvic ganglion. Neuroscience Letters, 403(1-2), 35-39. https://doi.org/10.1016/j.neulet.2006.04.051
Park, Jung Cheol ; Song, Dae Yong ; Lee, Jin Suk ; Kong, Indeok ; Jeong, Seong Woo ; Lee, Bong Hee ; Kang, Ho Suck ; Cho, Byung Pil. / Expression of GABAA receptor β2/3 subunits in the rat major pelvic ganglion. In: Neuroscience Letters. 2006 ; Vol. 403, No. 1-2. pp. 35-39.
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abstract = "Several pharmacological and physiological studies have suggested that GABAA receptors (GABAA Rs) may exist in the rat major pelvic ganglion (MPG), a large coalescent pelvic ganglion that contains both sympathetic and parasympathetic components which innervates pelvic organs. However, the presence of GABAA R in the MPG has never been demonstrated directly by morphological studies. In the present study, we used immunohistochemistry to demonstrate the existence of GABAA R β2/3 subunits for the first time in the rat MPG. We also analyzed the neurochemical properties of MPG neurons expressing GABAA R β2/3 subunits. GABAA R β2/3-immunoreactive (-IR) neurons occupied 27.4 ± 7.0{\%} of the whole neuronal population, and many of these (77.6{\%}) were co-localized with tyrosine hydroxylase (TH). Likewise, most (86.5{\%}) of TH-IR neurons were GABAA R β2/3-positive. GABAA R β2/3 subunits were also expressed in a few VIP- or NOS-IR neurons, the cholinergic or non-adrenergic, non-cholinergic (NANC) neurons. These results suggest that GABAA Rs are involved in the modulation of most sympathetic, noradrenergic neurons and also a subset of VIP and NOS neurons of the rat MPG.",
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Park, JC, Song, DY, Lee, JS, Kong, I, Jeong, SW, Lee, BH, Kang, HS & Cho, BP 2006, 'Expression of GABAA receptor β2/3 subunits in the rat major pelvic ganglion', Neuroscience Letters, vol. 403, no. 1-2, pp. 35-39. https://doi.org/10.1016/j.neulet.2006.04.051

Expression of GABAA receptor β2/3 subunits in the rat major pelvic ganglion. / Park, Jung Cheol; Song, Dae Yong; Lee, Jin Suk; Kong, Indeok; Jeong, Seong Woo; Lee, Bong Hee; Kang, Ho Suck; Cho, Byung Pil.

In: Neuroscience Letters, Vol. 403, No. 1-2, 31.07.2006, p. 35-39.

Research output: Contribution to journalArticle

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