Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma

B. S. Yoon, YoungTae Kim, J. W. Kim, S. H. Kim, Jae-Hoon Kim, S. W. Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer. Method: Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used. Result: Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046). Conclusion: HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume98
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

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HLA Antigens
Interleukin-10
Uterine Cervical Neoplasms
Carcinoma
Messenger RNA
Cervix Uteri
Real-Time Polymerase Chain Reaction
Carcinogenesis
Proteins
Western Blotting
Neoplasms

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

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title = "Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma",
abstract = "Objective: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer. Method: Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used. Result: Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046). Conclusion: HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.",
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Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma. / Yoon, B. S.; Kim, YoungTae; Kim, J. W.; Kim, S. H.; Kim, Jae-Hoon; Kim, S. W.

In: International Journal of Gynecology and Obstetrics, Vol. 98, No. 1, 01.01.2007, p. 48-53.

Research output: Contribution to journalArticle

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AU - Kim, J. W.

AU - Kim, S. H.

AU - Kim, Jae-Hoon

AU - Kim, S. W.

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N2 - Objective: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer. Method: Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used. Result: Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046). Conclusion: HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.

AB - Objective: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer. Method: Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used. Result: Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046). Conclusion: HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.

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