Abstract
Objective: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer. Method: Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used. Result: Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046). Conclusion: HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 48-53 |
| Number of pages | 6 |
| Journal | International Journal of Gynecology and Obstetrics |
| Volume | 98 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology
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Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma. / Yoon, B. S.; Kim, YoungTae; Kim, J. W.; Kim, S. H.; Kim, Jae-Hoon; Kim, S. W.
In: International Journal of Gynecology and Obstetrics, Vol. 98, No. 1, 01.01.2007, p. 48-53.Research output: Contribution to journal › Article
TY - JOUR
T1 - Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma
AU - Yoon, B. S.
AU - Kim, YoungTae
AU - Kim, J. W.
AU - Kim, S. H.
AU - Kim, Jae-Hoon
AU - Kim, S. W.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Objective: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer. Method: Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used. Result: Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046). Conclusion: HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.
AB - Objective: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer. Method: Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used. Result: Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046). Conclusion: HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.
UR - http://www.scopus.com/inward/record.url?scp=34250180590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250180590&partnerID=8YFLogxK
U2 - 10.1016/j.ijgo.2007.03.041
DO - 10.1016/j.ijgo.2007.03.041
M3 - Article
C2 - 17490670
AN - SCOPUS:34250180590
VL - 98
SP - 48
EP - 53
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
SN - 0020-7292
IS - 1
ER -