Expression of immediate early gene cyr61 during the differentiation of immortalized embryonic hippocampal neuronal cells

Kwang Chul Chung, Young Soo Ahn

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Growth factor-mediated signal transduction is a process that is of fundamental importance in understanding cellular growth and differentiation. In order to elucidate the signaling pathways leading to neuronal differentiation, we have tried to identify intermediates that are selectively induced in the differentiation of immortalized neuronal hippocampal cell line H19-7. In the present study we found that immediate early gene cyr61 is expressed in a rapid and transient manner by bFGF during the differentiation of H19-7 cells. To clarify the signal transduction pathway for the induction of cyr61 by bFGF, we checked whether Raf-1 and mitogen-activated protein kinase (MAPK) is activated during the induction of cyr61. It is identified that cyr61 is induced by bFGF via at least two signaling pathways; MAPK- dependent as well as MAPK-independent signaling pathways. This study suggested that cyr61 is likely to play an important role in neuronal differentiation process.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalNeuroscience Letters
Volume255
Issue number3
DOIs
Publication statusPublished - 1998 Oct 23

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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