Expression of interleukin-17 is correlated with interferon-α expression in cutaneous lesions of lupus erythematosus

S. H. Oh, H. J. Roh, J. E. Kwon, S. H. Lee, J. Y. Kim, H. J. Choi, B. J. Lim

Research output: Contribution to journalArticle

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Abstract

Background. Type I interferon (IFN) has been reported to have an important role in the development of cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). A new subset of CD4+ T cells, T helper (Th)17 cells, also plays a role in the development of autoimmunity. Aim. To investigate expression of interleukin (IL)-17 and IFN-α in different CLE subsets, and their associations with the pathogenesis of LE. Methods. Skin tissue samples from 33 cases, including chronic discoid LE (n=24), acute (A)CLE (n=4), subacute CLE (n=1) and lupus panniculitis (n=4) were collected for immunohistochemistry. Expression of IL-6, IL-17A, IFN-α, IFN-γ, myxovirus protein (Mx)A and transforming growth factor (TGF)-β was assessed in these samples. Results. All LE specimens had staining for IL-6 and TGF-β in the infiltrated inflammatory cells. IL-17A staining was seen in 84.8% of specimens, and IFN-α or MxA was seen in 93.9%. TGF-β expression in ACLE was significantly greater than that in both chronic cutaneous (CC)LE and in lupus panniculitis (P=0.02 for both). Expression of IL-17A was positively associated with expression of IFN-α and MxA (Spearman's ρ=0.56 and 0.39, respectively). In addition, the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) correlated positively with expression of IFN-α and MxA (ρ=0.40 for both), whereas there was no correlation with IL-17A expression. Conclusions. Two major cytokines, IL-17A and IFN-α, may play roles in the pathogenesis of CLE. Their patterns of expression positively correlated with each other.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalClinical and Experimental Dermatology
Volume36
Issue number5
DOIs
Publication statusPublished - 2011 Jul 1

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Cutaneous Lupus Erythematosus
Interleukin-17
Interferons
Lupus Erythematosus Panniculitis
Transforming Growth Factors
Interleukin-6
Myxovirus Resistance Proteins
Staining and Labeling
Th17 Cells
Interferon Type I
Skin
T-Lymphocyte Subsets
Orthomyxoviridae
Autoimmunity
Systemic Lupus Erythematosus
Immunohistochemistry
Cytokines

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Oh, S. H. ; Roh, H. J. ; Kwon, J. E. ; Lee, S. H. ; Kim, J. Y. ; Choi, H. J. ; Lim, B. J. / Expression of interleukin-17 is correlated with interferon-α expression in cutaneous lesions of lupus erythematosus. In: Clinical and Experimental Dermatology. 2011 ; Vol. 36, No. 5. pp. 512-520.
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title = "Expression of interleukin-17 is correlated with interferon-α expression in cutaneous lesions of lupus erythematosus",
abstract = "Background. Type I interferon (IFN) has been reported to have an important role in the development of cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). A new subset of CD4+ T cells, T helper (Th)17 cells, also plays a role in the development of autoimmunity. Aim. To investigate expression of interleukin (IL)-17 and IFN-α in different CLE subsets, and their associations with the pathogenesis of LE. Methods. Skin tissue samples from 33 cases, including chronic discoid LE (n=24), acute (A)CLE (n=4), subacute CLE (n=1) and lupus panniculitis (n=4) were collected for immunohistochemistry. Expression of IL-6, IL-17A, IFN-α, IFN-γ, myxovirus protein (Mx)A and transforming growth factor (TGF)-β was assessed in these samples. Results. All LE specimens had staining for IL-6 and TGF-β in the infiltrated inflammatory cells. IL-17A staining was seen in 84.8{\%} of specimens, and IFN-α or MxA was seen in 93.9{\%}. TGF-β expression in ACLE was significantly greater than that in both chronic cutaneous (CC)LE and in lupus panniculitis (P=0.02 for both). Expression of IL-17A was positively associated with expression of IFN-α and MxA (Spearman's ρ=0.56 and 0.39, respectively). In addition, the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) correlated positively with expression of IFN-α and MxA (ρ=0.40 for both), whereas there was no correlation with IL-17A expression. Conclusions. Two major cytokines, IL-17A and IFN-α, may play roles in the pathogenesis of CLE. Their patterns of expression positively correlated with each other.",
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Expression of interleukin-17 is correlated with interferon-α expression in cutaneous lesions of lupus erythematosus. / Oh, S. H.; Roh, H. J.; Kwon, J. E.; Lee, S. H.; Kim, J. Y.; Choi, H. J.; Lim, B. J.

In: Clinical and Experimental Dermatology, Vol. 36, No. 5, 01.07.2011, p. 512-520.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Expression of interleukin-17 is correlated with interferon-α expression in cutaneous lesions of lupus erythematosus

AU - Oh, S. H.

AU - Roh, H. J.

AU - Kwon, J. E.

AU - Lee, S. H.

AU - Kim, J. Y.

AU - Choi, H. J.

AU - Lim, B. J.

PY - 2011/7/1

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N2 - Background. Type I interferon (IFN) has been reported to have an important role in the development of cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). A new subset of CD4+ T cells, T helper (Th)17 cells, also plays a role in the development of autoimmunity. Aim. To investigate expression of interleukin (IL)-17 and IFN-α in different CLE subsets, and their associations with the pathogenesis of LE. Methods. Skin tissue samples from 33 cases, including chronic discoid LE (n=24), acute (A)CLE (n=4), subacute CLE (n=1) and lupus panniculitis (n=4) were collected for immunohistochemistry. Expression of IL-6, IL-17A, IFN-α, IFN-γ, myxovirus protein (Mx)A and transforming growth factor (TGF)-β was assessed in these samples. Results. All LE specimens had staining for IL-6 and TGF-β in the infiltrated inflammatory cells. IL-17A staining was seen in 84.8% of specimens, and IFN-α or MxA was seen in 93.9%. TGF-β expression in ACLE was significantly greater than that in both chronic cutaneous (CC)LE and in lupus panniculitis (P=0.02 for both). Expression of IL-17A was positively associated with expression of IFN-α and MxA (Spearman's ρ=0.56 and 0.39, respectively). In addition, the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) correlated positively with expression of IFN-α and MxA (ρ=0.40 for both), whereas there was no correlation with IL-17A expression. Conclusions. Two major cytokines, IL-17A and IFN-α, may play roles in the pathogenesis of CLE. Their patterns of expression positively correlated with each other.

AB - Background. Type I interferon (IFN) has been reported to have an important role in the development of cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). A new subset of CD4+ T cells, T helper (Th)17 cells, also plays a role in the development of autoimmunity. Aim. To investigate expression of interleukin (IL)-17 and IFN-α in different CLE subsets, and their associations with the pathogenesis of LE. Methods. Skin tissue samples from 33 cases, including chronic discoid LE (n=24), acute (A)CLE (n=4), subacute CLE (n=1) and lupus panniculitis (n=4) were collected for immunohistochemistry. Expression of IL-6, IL-17A, IFN-α, IFN-γ, myxovirus protein (Mx)A and transforming growth factor (TGF)-β was assessed in these samples. Results. All LE specimens had staining for IL-6 and TGF-β in the infiltrated inflammatory cells. IL-17A staining was seen in 84.8% of specimens, and IFN-α or MxA was seen in 93.9%. TGF-β expression in ACLE was significantly greater than that in both chronic cutaneous (CC)LE and in lupus panniculitis (P=0.02 for both). Expression of IL-17A was positively associated with expression of IFN-α and MxA (Spearman's ρ=0.56 and 0.39, respectively). In addition, the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) correlated positively with expression of IFN-α and MxA (ρ=0.40 for both), whereas there was no correlation with IL-17A expression. Conclusions. Two major cytokines, IL-17A and IFN-α, may play roles in the pathogenesis of CLE. Their patterns of expression positively correlated with each other.

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