Expression of lipid metabolism-related proteins in breast phyllodes tumors

Y. Y. Jung, Y. K. Lee, J. S. Koo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to investigate the expression of lipid metabolism-related proteins and the implications thereof in phyllodes tumor (PT) of the breast. A tissue microarray (TMA) was constructed using paraffin blocks from 194 PT patient tissue samples. Immunohistochemical staining for lipid metabolism-related proteins, namely hormone-sensitive lipase (HSL), perilipin 2, fatty-acid-binding proteins 4 (FABP4), carnitine palmitoyltransferase-1 (CPT-1), acyl-CoA oxidase 1 (ACOX-1), and fatty acid synthase (FASN) was performed, and the immunohistochemical staining results were analyzed with respect to clinicopathologic parameters. The numbers of benign, borderline, and malignant PTs were 151, 27, and 16, respectively. The expression of HSL, perilipin 2, FABP4, CPT-1, and FASN in stromal components was higher in higher grade tumors. On univariate analysis, shorter disease-free survival (DFS) was associated with stromal perilipin 2 positivity (p<0.001) and stromal CPT-1 positivity (p=0.004). Shorter overall survival (OS) was associated with stromal perilipin 2 positivity (p<0.001), stromal FABP4 positivity (p<0.001), stromal CPT-1 positivity (p=0.004), and stromal FASN positivity (p<0.001). Multivariate Cox analysis revealed that stromal perilipin 2 positivity (hazard ratio=31.693, 95% CI: 1.341-748.8, p=0.032) was an independent factor for shorter DFS. In conclusion, higher expressions of HSL, perilipin 2, FABP4, CPT-1 and FASN in the stromal component were observed in higher grade PT.

Original languageEnglish
Pages (from-to)254-262
Number of pages9
JournalNeoplasma
Volume63
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

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Phyllodes Tumor
Carnitine O-Palmitoyltransferase
Lipid Metabolism
Fatty Acid Synthases
Fatty Acid-Binding Proteins
Breast Neoplasms
Sterol Esterase
Proteins
Disease-Free Survival
Acyl-CoA Oxidase
Staining and Labeling
Paraffin
Perilipin-2
Breast
Multivariate Analysis
Survival

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Jung, Y. Y. ; Lee, Y. K. ; Koo, J. S. / Expression of lipid metabolism-related proteins in breast phyllodes tumors. In: Neoplasma. 2016 ; Vol. 63, No. 2. pp. 254-262.
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Expression of lipid metabolism-related proteins in breast phyllodes tumors. / Jung, Y. Y.; Lee, Y. K.; Koo, J. S.

In: Neoplasma, Vol. 63, No. 2, 01.01.2016, p. 254-262.

Research output: Contribution to journalArticle

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