Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast

Dokyung Kim, Woo Hee Jung, Ja Seung Koo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: The purpose of this study was to investigate the expression of MUC1, MUC2, MUC5AC and MUC5B in breast mucinous lesions. Methods: Immunohistochemical staining of MUC1, MUC2, MUC5AC, MUC5B and synaptophysin was performed in 78 cases of mucinous carcinoma (MC), 36 cases of mucocele-like lesions (MLL) and 13 cases of solid papillary carcinoma (SPC). MC was classified as type A or type B and MLL was classified as MLL, MLL with atypical ductal hyperplasia and MLL with ductal carcinoma in situ. Results: MUC1 was expressed in MC type A and MLL with luminal/apical pattern, while MC type B and SPC showed membrano-cytoplasmic expression of MUC1 (p < 0.001). A luminal/apical or luminal/apical + cytoplasmic pattern of MUC2 expression was observed in MC type A, while MC type B and SPC showed membrano-cytoplasmic MUC2 expression (p < 0.001). On MUC5B staining, MC type A and MLL were negative, while MC type B and SPC showed membrano-cytoplasmic expression (p = 0.011). The positive rate for synaptophysin was higher in MC type B and SPC than in MLL and MC type A (p = 0.001). Conclusions: Similar MUC phenotypes were observed between MLL and MC type A and between MC type B and SPC.

Original languageEnglish
Pages (from-to)144-153
Number of pages10
JournalPathobiology
Volume79
Issue number3
DOIs
Publication statusPublished - 2012 Mar 1

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Mucinous Adenocarcinoma
Mucocele
Breast
Papillary Carcinoma
Synaptophysin
Carcinoma, Intraductal, Noninfiltrating
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Kim, Dokyung ; Jung, Woo Hee ; Koo, Ja Seung. / Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast. In: Pathobiology. 2012 ; Vol. 79, No. 3. pp. 144-153.
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Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast. / Kim, Dokyung; Jung, Woo Hee; Koo, Ja Seung.

In: Pathobiology, Vol. 79, No. 3, 01.03.2012, p. 144-153.

Research output: Contribution to journalArticle

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AU - Jung, Woo Hee

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N2 - Objective: The purpose of this study was to investigate the expression of MUC1, MUC2, MUC5AC and MUC5B in breast mucinous lesions. Methods: Immunohistochemical staining of MUC1, MUC2, MUC5AC, MUC5B and synaptophysin was performed in 78 cases of mucinous carcinoma (MC), 36 cases of mucocele-like lesions (MLL) and 13 cases of solid papillary carcinoma (SPC). MC was classified as type A or type B and MLL was classified as MLL, MLL with atypical ductal hyperplasia and MLL with ductal carcinoma in situ. Results: MUC1 was expressed in MC type A and MLL with luminal/apical pattern, while MC type B and SPC showed membrano-cytoplasmic expression of MUC1 (p < 0.001). A luminal/apical or luminal/apical + cytoplasmic pattern of MUC2 expression was observed in MC type A, while MC type B and SPC showed membrano-cytoplasmic MUC2 expression (p < 0.001). On MUC5B staining, MC type A and MLL were negative, while MC type B and SPC showed membrano-cytoplasmic expression (p = 0.011). The positive rate for synaptophysin was higher in MC type B and SPC than in MLL and MC type A (p = 0.001). Conclusions: Similar MUC phenotypes were observed between MLL and MC type A and between MC type B and SPC.

AB - Objective: The purpose of this study was to investigate the expression of MUC1, MUC2, MUC5AC and MUC5B in breast mucinous lesions. Methods: Immunohistochemical staining of MUC1, MUC2, MUC5AC, MUC5B and synaptophysin was performed in 78 cases of mucinous carcinoma (MC), 36 cases of mucocele-like lesions (MLL) and 13 cases of solid papillary carcinoma (SPC). MC was classified as type A or type B and MLL was classified as MLL, MLL with atypical ductal hyperplasia and MLL with ductal carcinoma in situ. Results: MUC1 was expressed in MC type A and MLL with luminal/apical pattern, while MC type B and SPC showed membrano-cytoplasmic expression of MUC1 (p < 0.001). A luminal/apical or luminal/apical + cytoplasmic pattern of MUC2 expression was observed in MC type A, while MC type B and SPC showed membrano-cytoplasmic MUC2 expression (p < 0.001). On MUC5B staining, MC type A and MLL were negative, while MC type B and SPC showed membrano-cytoplasmic expression (p = 0.011). The positive rate for synaptophysin was higher in MC type B and SPC than in MLL and MC type A (p = 0.001). Conclusions: Similar MUC phenotypes were observed between MLL and MC type A and between MC type B and SPC.

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