Expression of neurotrophin receptors in surgically resected thymic epithelial tumors

Joon Kim Dae, Woo Ick Yang, Hoon Kim Se, In Kyu Park, Young Chung Kyung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Neurotrophins are known to exert a variety of pleiotropic responses in different target tissues, but little is known about their effect on thymic epithelial tumors. Therefore, we analyzed the expression of neurotrophin receptors in surgically resected thymic epithelial tumors and evaluated their clinical relevance. Methods: The expression of neurotrophin receptors (Trk-A, Trk-B, Trk-C and p75NTR) in thymic epithelial tumors was evaluated in 99 consecutive patients based on immunohistochemical staining. The pattern of expression was analyzed according to the WHO classification, and survival outcomes were estimated. Results: Thymic tumors were classified as type A (n=6), AB (n=21), B1 (n=15), B2 (n=24), B3 (n=22) or C (n=11). All tumors, except one type C thymoma, demonstrated cytoplasmic Trk-A immunostaining, and no thymic tumors showed Trk-B or Trk-C immunoreactivity. p75NTR immunostaining demonstrated characteristic patterns according to the WHO subtypes of thymomas. All type A and type AB thymomas showed p75NTR immunoreactivity, except one type A tumor. The expression of p75NTR was negative in 6 patients (40%) with type B1 thymomas, 19 patients (79.2%) with type B2 thymomas, 17 patients (77.3%) with type B3 thymomas and 10 patients (90.9%) with type C thymomas. Tumor-related survival at 5 and 10 years was 95.5 and 89.5%, respectively, in p75NTR-positive thymomas and 82.8 and 77.2%, respectively, in p75NTR-negative thymomas; however, the differences were not statistically significant (P=0.14). Conclusions: Among the neurotrophin receptors examined, the pattern of p75NTR expression closely correlated with the WHO subtypes of thymomas. Further study of p75NTR expression may aid in understanding the biology of thymic epithelial tumors.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalEuropean Journal of Cardio-thoracic Surgery
Volume28
Issue number4
DOIs
Publication statusPublished - 2005 Oct 1

Fingerprint

Nerve Growth Factor Receptors
Thymoma
Thymus Neoplasms
Thymic epithelial tumor
Neoplasms
Survival
Nerve Growth Factors
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Dae, Joon Kim ; Yang, Woo Ick ; Se, Hoon Kim ; Park, In Kyu ; Kyung, Young Chung. / Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. In: European Journal of Cardio-thoracic Surgery. 2005 ; Vol. 28, No. 4. pp. 611-616.
@article{f4cc8efa7f53451d9e0934f1ad7148e6,
title = "Expression of neurotrophin receptors in surgically resected thymic epithelial tumors",
abstract = "Objective: Neurotrophins are known to exert a variety of pleiotropic responses in different target tissues, but little is known about their effect on thymic epithelial tumors. Therefore, we analyzed the expression of neurotrophin receptors in surgically resected thymic epithelial tumors and evaluated their clinical relevance. Methods: The expression of neurotrophin receptors (Trk-A, Trk-B, Trk-C and p75NTR) in thymic epithelial tumors was evaluated in 99 consecutive patients based on immunohistochemical staining. The pattern of expression was analyzed according to the WHO classification, and survival outcomes were estimated. Results: Thymic tumors were classified as type A (n=6), AB (n=21), B1 (n=15), B2 (n=24), B3 (n=22) or C (n=11). All tumors, except one type C thymoma, demonstrated cytoplasmic Trk-A immunostaining, and no thymic tumors showed Trk-B or Trk-C immunoreactivity. p75NTR immunostaining demonstrated characteristic patterns according to the WHO subtypes of thymomas. All type A and type AB thymomas showed p75NTR immunoreactivity, except one type A tumor. The expression of p75NTR was negative in 6 patients (40{\%}) with type B1 thymomas, 19 patients (79.2{\%}) with type B2 thymomas, 17 patients (77.3{\%}) with type B3 thymomas and 10 patients (90.9{\%}) with type C thymomas. Tumor-related survival at 5 and 10 years was 95.5 and 89.5{\%}, respectively, in p75NTR-positive thymomas and 82.8 and 77.2{\%}, respectively, in p75NTR-negative thymomas; however, the differences were not statistically significant (P=0.14). Conclusions: Among the neurotrophin receptors examined, the pattern of p75NTR expression closely correlated with the WHO subtypes of thymomas. Further study of p75NTR expression may aid in understanding the biology of thymic epithelial tumors.",
author = "Dae, {Joon Kim} and Yang, {Woo Ick} and Se, {Hoon Kim} and Park, {In Kyu} and Kyung, {Young Chung}",
year = "2005",
month = "10",
day = "1",
doi = "10.1016/j.ejcts.2005.06.034",
language = "English",
volume = "28",
pages = "611--616",
journal = "European Journal of Cardio-thoracic Surgery",
issn = "1010-7940",
publisher = "Elsevier",
number = "4",

}

Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. / Dae, Joon Kim; Yang, Woo Ick; Se, Hoon Kim; Park, In Kyu; Kyung, Young Chung.

In: European Journal of Cardio-thoracic Surgery, Vol. 28, No. 4, 01.10.2005, p. 611-616.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Expression of neurotrophin receptors in surgically resected thymic epithelial tumors

AU - Dae, Joon Kim

AU - Yang, Woo Ick

AU - Se, Hoon Kim

AU - Park, In Kyu

AU - Kyung, Young Chung

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Objective: Neurotrophins are known to exert a variety of pleiotropic responses in different target tissues, but little is known about their effect on thymic epithelial tumors. Therefore, we analyzed the expression of neurotrophin receptors in surgically resected thymic epithelial tumors and evaluated their clinical relevance. Methods: The expression of neurotrophin receptors (Trk-A, Trk-B, Trk-C and p75NTR) in thymic epithelial tumors was evaluated in 99 consecutive patients based on immunohistochemical staining. The pattern of expression was analyzed according to the WHO classification, and survival outcomes were estimated. Results: Thymic tumors were classified as type A (n=6), AB (n=21), B1 (n=15), B2 (n=24), B3 (n=22) or C (n=11). All tumors, except one type C thymoma, demonstrated cytoplasmic Trk-A immunostaining, and no thymic tumors showed Trk-B or Trk-C immunoreactivity. p75NTR immunostaining demonstrated characteristic patterns according to the WHO subtypes of thymomas. All type A and type AB thymomas showed p75NTR immunoreactivity, except one type A tumor. The expression of p75NTR was negative in 6 patients (40%) with type B1 thymomas, 19 patients (79.2%) with type B2 thymomas, 17 patients (77.3%) with type B3 thymomas and 10 patients (90.9%) with type C thymomas. Tumor-related survival at 5 and 10 years was 95.5 and 89.5%, respectively, in p75NTR-positive thymomas and 82.8 and 77.2%, respectively, in p75NTR-negative thymomas; however, the differences were not statistically significant (P=0.14). Conclusions: Among the neurotrophin receptors examined, the pattern of p75NTR expression closely correlated with the WHO subtypes of thymomas. Further study of p75NTR expression may aid in understanding the biology of thymic epithelial tumors.

AB - Objective: Neurotrophins are known to exert a variety of pleiotropic responses in different target tissues, but little is known about their effect on thymic epithelial tumors. Therefore, we analyzed the expression of neurotrophin receptors in surgically resected thymic epithelial tumors and evaluated their clinical relevance. Methods: The expression of neurotrophin receptors (Trk-A, Trk-B, Trk-C and p75NTR) in thymic epithelial tumors was evaluated in 99 consecutive patients based on immunohistochemical staining. The pattern of expression was analyzed according to the WHO classification, and survival outcomes were estimated. Results: Thymic tumors were classified as type A (n=6), AB (n=21), B1 (n=15), B2 (n=24), B3 (n=22) or C (n=11). All tumors, except one type C thymoma, demonstrated cytoplasmic Trk-A immunostaining, and no thymic tumors showed Trk-B or Trk-C immunoreactivity. p75NTR immunostaining demonstrated characteristic patterns according to the WHO subtypes of thymomas. All type A and type AB thymomas showed p75NTR immunoreactivity, except one type A tumor. The expression of p75NTR was negative in 6 patients (40%) with type B1 thymomas, 19 patients (79.2%) with type B2 thymomas, 17 patients (77.3%) with type B3 thymomas and 10 patients (90.9%) with type C thymomas. Tumor-related survival at 5 and 10 years was 95.5 and 89.5%, respectively, in p75NTR-positive thymomas and 82.8 and 77.2%, respectively, in p75NTR-negative thymomas; however, the differences were not statistically significant (P=0.14). Conclusions: Among the neurotrophin receptors examined, the pattern of p75NTR expression closely correlated with the WHO subtypes of thymomas. Further study of p75NTR expression may aid in understanding the biology of thymic epithelial tumors.

UR - http://www.scopus.com/inward/record.url?scp=25144438475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25144438475&partnerID=8YFLogxK

U2 - 10.1016/j.ejcts.2005.06.034

DO - 10.1016/j.ejcts.2005.06.034

M3 - Article

C2 - 16125946

AN - SCOPUS:25144438475

VL - 28

SP - 611

EP - 616

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

IS - 4

ER -