Expression of osteopontin in calcified coronary atherosclerotic plaques

Hyuck Moon Kwon, Bum Kee Hong, Tae Soo Kang, Kihwan Kwon, Hae Kyoon Kim, Yangsoo Jang, Donghoon Choi, Hyun Young Park, seokmin kang, Seung Yun Cho, Hyun Seung Kim

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Advanced atherosclerosis is often associated with dystrophic calcification and remodeling of extracellular matrix of vascular wall. Recently many studies have documented a general relationship between calcification and severity of coronary disease, and discussed the feasibility of electron beam computed tomography for detecting and quantifying the coronary artery calcification in the patients. The present study investigated the expression and the localization of osteopontin, one of noncollagenous bone matrix protein, within the calcified coronary arteries. Autopsy-derived coronary artery specimens were scanned and reconstructed to visualize the pattern of coronary calcification using a novel microscopic computed tomography technique. The localization of the osteopontin were evaluated by immunohistochemial stain with LF7. The present study showed that the pattern of coronary calcification is variable and the expression of osteopontin is localized mainly to calcified lesion. The smooth muscle cells in addition to macrophage expressed osteopontin protein in human coronary atherosclerotic plaques. Soluble osteopontin released near to the sites of vascular calcification may represent an adaptive mechanism aimed at regulating the process of vascular calcification.

Original languageEnglish
Pages (from-to)485-493
Number of pages9
JournalJournal of Korean medical science
Volume15
Issue number5
DOIs
Publication statusPublished - 2000 Jan 1

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Osteopontin
Atherosclerotic Plaques
Vascular Calcification
Coronary Vessels
Bone Matrix
X Ray Computed Tomography
Smooth Muscle Myocytes
Extracellular Matrix
Coronary Disease
Blood Vessels
Autopsy
Atherosclerosis
Proteins
Coloring Agents
Macrophages
Tomography

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kwon, H. M., Hong, B. K., Kang, T. S., Kwon, K., Kim, H. K., Jang, Y., ... Kim, H. S. (2000). Expression of osteopontin in calcified coronary atherosclerotic plaques. Journal of Korean medical science, 15(5), 485-493. https://doi.org/10.3346/jkms.2000.15.5.485
Kwon, Hyuck Moon ; Hong, Bum Kee ; Kang, Tae Soo ; Kwon, Kihwan ; Kim, Hae Kyoon ; Jang, Yangsoo ; Choi, Donghoon ; Park, Hyun Young ; kang, seokmin ; Cho, Seung Yun ; Kim, Hyun Seung. / Expression of osteopontin in calcified coronary atherosclerotic plaques. In: Journal of Korean medical science. 2000 ; Vol. 15, No. 5. pp. 485-493.
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Kwon, HM, Hong, BK, Kang, TS, Kwon, K, Kim, HK, Jang, Y, Choi, D, Park, HY, kang, S, Cho, SY & Kim, HS 2000, 'Expression of osteopontin in calcified coronary atherosclerotic plaques', Journal of Korean medical science, vol. 15, no. 5, pp. 485-493. https://doi.org/10.3346/jkms.2000.15.5.485

Expression of osteopontin in calcified coronary atherosclerotic plaques. / Kwon, Hyuck Moon; Hong, Bum Kee; Kang, Tae Soo; Kwon, Kihwan; Kim, Hae Kyoon; Jang, Yangsoo; Choi, Donghoon; Park, Hyun Young; kang, seokmin; Cho, Seung Yun; Kim, Hyun Seung.

In: Journal of Korean medical science, Vol. 15, No. 5, 01.01.2000, p. 485-493.

Research output: Contribution to journalArticle

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AU - Choi, Donghoon

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AU - Kim, Hyun Seung

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