Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

Kyoung Won Cho; Sung Won Cho; Jong Min Lee; Min Jung Lee; Hee Seok Gang; Han Sung Jung

doi:10.1016/j.gep.2007.12.001

Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

Kyoung Won Cho, Sung Won Cho, Jong Min Lee, Min Jung Lee, Hee Seok Gang, Han Sung Jung

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.

Original language	English
Pages (from-to)	284-290
Number of pages	7
Journal	Gene Expression Patterns
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.gep.2007.12.001
Publication status	Published - 2008 Apr

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (No. M10646010001-06N4601-00110).

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Developmental Biology

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10.1016/j.gep.2007.12.001

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title = "Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development",

abstract = "Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.",

author = "Cho, {Kyoung Won} and Cho, {Sung Won} and Lee, {Jong Min} and Lee, {Min Jung} and Gang, {Hee Seok} and Jung, {Han Sung}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (No. M10646010001-06N4601-00110).",

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doi = "10.1016/j.gep.2007.12.001",

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AU - Lee, Jong Min

AU - Lee, Min Jung

AU - Gang, Hee Seok

AU - Jung, Han Sung

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (No. M10646010001-06N4601-00110).

PY - 2008/4

Y1 - 2008/4

N2 - Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.

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Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

Abstract

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