Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

Kyoung Won Cho, Sung Won Cho, Jong Min Lee, Min Jung Lee, Hee Seok Gang, Hansung Jung

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalGene Expression Patterns
Volume8
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

Fingerprint

Phosphatidylinositol 3-Kinase
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Intercellular Signaling Peptides and Proteins
Chromosomes, Human, Pair 10
Phosphoric Monoester Hydrolases
Tongue
Vertebrates
Cell Differentiation
Tooth
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Developmental Biology

Cite this

Cho, Kyoung Won ; Cho, Sung Won ; Lee, Jong Min ; Lee, Min Jung ; Gang, Hee Seok ; Jung, Hansung. / Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development. In: Gene Expression Patterns. 2008 ; Vol. 8, No. 4. pp. 284-290.
@article{959082cb12c74310a1174018434b7e46,
title = "Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development",
abstract = "Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.",
author = "Cho, {Kyoung Won} and Cho, {Sung Won} and Lee, {Jong Min} and Lee, {Min Jung} and Gang, {Hee Seok} and Hansung Jung",
year = "2008",
month = "4",
day = "1",
doi = "10.1016/j.gep.2007.12.001",
language = "English",
volume = "8",
pages = "284--290",
journal = "Brain research. Gene expression patterns",
issn = "1567-133X",
publisher = "Elsevier",
number = "4",

}

Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development. / Cho, Kyoung Won; Cho, Sung Won; Lee, Jong Min; Lee, Min Jung; Gang, Hee Seok; Jung, Hansung.

In: Gene Expression Patterns, Vol. 8, No. 4, 01.04.2008, p. 284-290.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

AU - Cho, Kyoung Won

AU - Cho, Sung Won

AU - Lee, Jong Min

AU - Lee, Min Jung

AU - Gang, Hee Seok

AU - Jung, Hansung

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.

AB - Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue.

UR - http://www.scopus.com/inward/record.url?scp=39649123721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39649123721&partnerID=8YFLogxK

U2 - 10.1016/j.gep.2007.12.001

DO - 10.1016/j.gep.2007.12.001

M3 - Article

VL - 8

SP - 284

EP - 290

JO - Brain research. Gene expression patterns

JF - Brain research. Gene expression patterns

SN - 1567-133X

IS - 4

ER -