Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors

Eunah Shin, Ja Seung Koo

Research output: Contribution to journalArticle

Abstract

Background: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. Methods: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX-LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. Results: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. Conclusion: Proteins related to the ATX-LPA axis showed different levels of expression in primary thyroid tumors according to subtype.

Original languageEnglish
Article number288
JournalJournal of translational medicine
Volume17
Issue number1
DOIs
Publication statusPublished - 2019 Aug 28

Fingerprint

Tumors
Thyroid Gland
Carcinoma
Neoplasms
Proteins
Medullary Carcinoma
Microarrays
Coloring Agents
Tissue
Mutation
Papillary Thyroid cancer

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{95198fa8697e4c0aac566a2b0e5830e2,
title = "Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors",
abstract = "Background: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. Methods: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX-LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. Results: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. Conclusion: Proteins related to the ATX-LPA axis showed different levels of expression in primary thyroid tumors according to subtype.",
author = "Eunah Shin and Koo, {Ja Seung}",
year = "2019",
month = "8",
day = "28",
doi = "10.1186/s12967-019-2028-7",
language = "English",
volume = "17",
journal = "Journal of Translational Medicine",
issn = "1479-5876",
publisher = "BioMed Central",
number = "1",

}

Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors. / Shin, Eunah; Koo, Ja Seung.

In: Journal of translational medicine, Vol. 17, No. 1, 288, 28.08.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors

AU - Shin, Eunah

AU - Koo, Ja Seung

PY - 2019/8/28

Y1 - 2019/8/28

N2 - Background: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. Methods: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX-LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. Results: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. Conclusion: Proteins related to the ATX-LPA axis showed different levels of expression in primary thyroid tumors according to subtype.

AB - Background: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. Methods: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX-LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. Results: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. Conclusion: Proteins related to the ATX-LPA axis showed different levels of expression in primary thyroid tumors according to subtype.

UR - http://www.scopus.com/inward/record.url?scp=85071618886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071618886&partnerID=8YFLogxK

U2 - 10.1186/s12967-019-2028-7

DO - 10.1186/s12967-019-2028-7

M3 - Article

C2 - 31455351

AN - SCOPUS:85071618886

VL - 17

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

SN - 1479-5876

IS - 1

M1 - 288

ER -