Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater

Hyunsoo Kim, Sun Ho Lee, Kyu Yeoun Won, Gou Young Kim, Yong Koo Park, Youn Wha Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human malignancies. We have recently demonstrated that reduced expression of RKIP is significantly associated with invasion and metastasis in periampullary carcinomas, including pancreatic carcinoma, gallbladder carcinoma, and extrahepatic bile duct carcinoma. In this study, we evaluated RKIP expression in ampulla of Vater (AoV) carcinoma and investigated its prognostic significance. Immunostaining for RKIP was performed for 80 and 21 cases with primary and nodal metastatic AoV carcinoma, respectively. RKIP expression was reduced in 32.5% (26/80) and 66.7% (14/21) of primary and nodal metastatic AoV carcinoma cases, respectively. This distribution of RKIP expression was statistically significant (P<0.001). The reduction in RKIP expression was significantly associated with the presence of nodal (P=0.008) and distant (P=0.002) metastases, a higher TNM stage group (P=0.010), lymphatic invasion (P<0.001), vascular invasion (P<0.001), and a shorter disease-free survival (DFS; P= 0.028) and distant metastasis-free survival (DMFS; P= 0.005). In addition, reduced RKIP expression was an independent prognostic predictor for worse DFS and DMFS (P=0.032 and P=0.036, respectively). Our data suggest that a reduction in RKIP expression contributes to invasion and metastasis in AoV carcinoma and is a significant prognostic marker in patients with AoV carcinoma.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalVirchows Archiv
Volume460
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Phosphatidylethanolamine Binding Protein
Proto-Oncogene Proteins c-raf
Ampulla of Vater
Carcinoma
Proteins
Neoplasm Metastasis
Extrahepatic Bile Ducts
Gallbladder
Disease-Free Survival
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Kim, Hyunsoo ; Lee, Sun Ho ; Won, Kyu Yeoun ; Kim, Gou Young ; Park, Yong Koo ; Kim, Youn Wha. / Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater. In: Virchows Archiv. 2012 ; Vol. 460, No. 1. pp. 61-68.
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abstract = "Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human malignancies. We have recently demonstrated that reduced expression of RKIP is significantly associated with invasion and metastasis in periampullary carcinomas, including pancreatic carcinoma, gallbladder carcinoma, and extrahepatic bile duct carcinoma. In this study, we evaluated RKIP expression in ampulla of Vater (AoV) carcinoma and investigated its prognostic significance. Immunostaining for RKIP was performed for 80 and 21 cases with primary and nodal metastatic AoV carcinoma, respectively. RKIP expression was reduced in 32.5{\%} (26/80) and 66.7{\%} (14/21) of primary and nodal metastatic AoV carcinoma cases, respectively. This distribution of RKIP expression was statistically significant (P<0.001). The reduction in RKIP expression was significantly associated with the presence of nodal (P=0.008) and distant (P=0.002) metastases, a higher TNM stage group (P=0.010), lymphatic invasion (P<0.001), vascular invasion (P<0.001), and a shorter disease-free survival (DFS; P= 0.028) and distant metastasis-free survival (DMFS; P= 0.005). In addition, reduced RKIP expression was an independent prognostic predictor for worse DFS and DMFS (P=0.032 and P=0.036, respectively). Our data suggest that a reduction in RKIP expression contributes to invasion and metastasis in AoV carcinoma and is a significant prognostic marker in patients with AoV carcinoma.",
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Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater. / Kim, Hyunsoo; Lee, Sun Ho; Won, Kyu Yeoun; Kim, Gou Young; Park, Yong Koo; Kim, Youn Wha.

In: Virchows Archiv, Vol. 460, No. 1, 01.01.2012, p. 61-68.

Research output: Contribution to journalArticle

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T1 - Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater

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AU - Lee, Sun Ho

AU - Won, Kyu Yeoun

AU - Kim, Gou Young

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AB - Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human malignancies. We have recently demonstrated that reduced expression of RKIP is significantly associated with invasion and metastasis in periampullary carcinomas, including pancreatic carcinoma, gallbladder carcinoma, and extrahepatic bile duct carcinoma. In this study, we evaluated RKIP expression in ampulla of Vater (AoV) carcinoma and investigated its prognostic significance. Immunostaining for RKIP was performed for 80 and 21 cases with primary and nodal metastatic AoV carcinoma, respectively. RKIP expression was reduced in 32.5% (26/80) and 66.7% (14/21) of primary and nodal metastatic AoV carcinoma cases, respectively. This distribution of RKIP expression was statistically significant (P<0.001). The reduction in RKIP expression was significantly associated with the presence of nodal (P=0.008) and distant (P=0.002) metastases, a higher TNM stage group (P=0.010), lymphatic invasion (P<0.001), vascular invasion (P<0.001), and a shorter disease-free survival (DFS; P= 0.028) and distant metastasis-free survival (DMFS; P= 0.005). In addition, reduced RKIP expression was an independent prognostic predictor for worse DFS and DMFS (P=0.032 and P=0.036, respectively). Our data suggest that a reduction in RKIP expression contributes to invasion and metastasis in AoV carcinoma and is a significant prognostic marker in patients with AoV carcinoma.

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