Expression of stress-induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer

Hanbyoul Cho, Sunghoon Kim, Ha Yeon Shin, Eun Joo Chung, Haruhisa Kitano, Jae Hyon Park, Lucienne Park, Joon Yong Chung, Stephen M. Hewitt, Jae Hoon Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Stress-induced phosphoprotein1 (STIP1) is a candidate biomarker in epithelial ovarian cancer (EOC). In this study, we investigated in detail the expression of STIP1, as well as its functions, in EOC. STIP1 expression was assessed by immunohistochemistry (IHC) and the results were compared with clinicopathologic factors, including survival data. The effects of STIP1 gene silencing via small interfering RNA (siRNA) were examined in EOC cells and a xenograft model. The expression of STIP1 protein in EOC was significantly higher than in the other study groups (P<0.001), and this increase of expression was significantly associated with tumor stage (P=0.005), tumor grade (P=0.029), and lymph node metastasis (P=0.020). In multivariate analysis, overall survival in EOC was significantly shorter in cases with high STIP1 expression (HR=2.78 [1.01-7.63], P=0.047). STIP1 silencing in EOC cells resulted in inhibition of cell proliferation and invasion. In addition, in vivo experiments using STIP1 siRNA clearly showed a strong inhibition of tumor growth and a modulation of expression of prosurvival and apoptotic genes, further suggesting that STIP1 silencing can prevent cell proliferation and invasion. In conclusion, increased STIP1 expression is associated with poor survival outcome in EOC, and STIP1 may represent a useful therapeutic target in EOC patients.

Original languageEnglish
Pages (from-to)277-288
Number of pages12
JournalGenes Chromosomes and Cancer
Volume53
Issue number4
DOIs
Publication statusPublished - 2014 Apr 1

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

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