Expression of UTX Indicates Poor Prognosis in Patients with Luminal Breast Cancer and is Associated with MMP-11 Expression

Gi Jeong Kim, Dong Hoon Kim, Kyueng Whan Min, Seoung Wan Chae, Se Hoon Kim, Byoung Kwan Son, Kyoung Min Moon, Young Hwan Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival; P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer.

Original languageEnglish
Pages (from-to)544-550
Number of pages7
JournalApplied Immunohistochemistry and Molecular Morphology
Volume28
Issue number7
DOIs
Publication statusPublished - 2020 Aug 1

Bibliographical note

Funding Information:
Supported by the research fund of Hanyang University (HY-2019).

Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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