Expression patterns of the Fam83h gene during murine tooth development

Min Jung Lee, Sook Kyung Lee, Kyung Eun Lee, Hee Yun Kang, Han Sung Jung, Jung Wook Kim

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19 Citations (Scopus)


Aim: Recently a novel gene, FAM83H, was identified by a genetic linkage study in the hypocalcified form of the amelogenesis imperfecta family with an autosomal dominant hereditary pattern. Little is known about this novel gene, and so we investigated the expression pattern of Fam83h in murine tooth development using serial sectional in situ hybridisation. Methods and Materials: Using mandibles of ICR mouse at specific developmental stages, in situ hybridisation was performed by DIG-labeled RNA probe. Results: Faint expression was detected in limited cells at embryonic day 14 (E14) in the molar. At the bell stage, E16, Fam83h was localised in the outer and inner enamel epithelium, as well as dental papilla. Fam83h expression begins on E15 in the developing incisor. At E18, Fam83h was expressed in the inner enamel epithelium of the apical bud, ameloblasts and odontoblasts. The expression was stronger in the presecretory stages than the secretory stages. Conclusion: Fam83h was detected in the ameloblasts from the presecretory to the secretory stage, and also the odontoblasts layer and surrounding alveolar bone.

Original languageEnglish
Pages (from-to)846-850
Number of pages5
JournalArchives of Oral Biology
Issue number9
Publication statusPublished - 2009 Sept

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. R01-2008-000-10174-0(2008)) and by the Korea Research Foundation Grant funded by the Korean Government (KRF-2008-313-E00597).

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology


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