Extensively drug-resistant Acinetobacter baumannii: Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study

Yoon Soo Park; Hyukmin Lee; Kkot Sil Lee; Seung Sik Hwang; Yong Kyun Cho; Hyo Youl Kim; Young Uh; Bum Sik Chin; Sang Hoon Han; Seok Hoon Jeong; Kyungwon Lee; June Myung Kim

doi:10.1016/j.ijantimicag.2010.06.049

Extensively drug-resistant Acinetobacter baumannii: Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study

Yoon Soo Park, Hyukmin Lee, Kkot Sil Lee, Seung Sik Hwang, Yong Kyun Cho, Hyo Youl Kim, Young Uh, Bum Sik Chin, Sang Hoon Han, Seok Hoon Jeong, Kyungwon Lee, June Myung Kim

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case-control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3-171.3 P= 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1-1.5; P= 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.

Original language	English
Pages (from-to)	430-435
Number of pages	6
Journal	International Journal of Antimicrobial Agents
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/j.ijantimicag.2010.06.049
Publication status	Published - 2010 Nov

Bibliographical note

Funding Information:
Funding : This work was partly supported by the National Institute of Health, Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare, Republic of Korea (grant no. 2007-S3-G-004 ).

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2010.06.049

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Park, Y. S., Lee, H., Lee, K. S., Hwang, S. S., Cho, Y. K., Kim, H. Y., Uh, Y., Chin, B. S., Han, S. H., Jeong, S. H., Lee, K., & Kim, J. M. (2010). Extensively drug-resistant Acinetobacter baumannii: Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study. International Journal of Antimicrobial Agents, 36(5), 430-435. https://doi.org/10.1016/j.ijantimicag.2010.06.049

@article{cea5c0f5c3e947d7b6073b500c9b294b,

title = "Extensively drug-resistant Acinetobacter baumannii: Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study",

abstract = "In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case-control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3-171.3 P= 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1-1.5; P= 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.",

author = "Park, {Yoon Soo} and Hyukmin Lee and Lee, {Kkot Sil} and Hwang, {Seung Sik} and Cho, {Yong Kyun} and Kim, {Hyo Youl} and Young Uh and Chin, {Bum Sik} and Han, {Sang Hoon} and Jeong, {Seok Hoon} and Kyungwon Lee and Kim, {June Myung}",

note = "Funding Information: Funding : This work was partly supported by the National Institute of Health, Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare, Republic of Korea (grant no. 2007-S3-G-004 ). ",

year = "2010",

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doi = "10.1016/j.ijantimicag.2010.06.049",

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Park, YS, Lee, H, Lee, KS, Hwang, SS, Cho, YK, Kim, HY, Uh, Y, Chin, BS, Han, SH, Jeong, SH , Lee, K & Kim, JM 2010, 'Extensively drug-resistant Acinetobacter baumannii: Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study', International Journal of Antimicrobial Agents, vol. 36, no. 5, pp. 430-435. https://doi.org/10.1016/j.ijantimicag.2010.06.049

TY - JOUR

T1 - Extensively drug-resistant Acinetobacter baumannii

T2 - Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study

AU - Park, Yoon Soo

AU - Lee, Hyukmin

AU - Lee, Kkot Sil

AU - Hwang, Seung Sik

AU - Cho, Yong Kyun

AU - Kim, Hyo Youl

AU - Uh, Young

AU - Chin, Bum Sik

AU - Han, Sang Hoon

AU - Jeong, Seok Hoon

AU - Lee, Kyungwon

AU - Kim, June Myung

N1 - Funding Information: Funding : This work was partly supported by the National Institute of Health, Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare, Republic of Korea (grant no. 2007-S3-G-004 ).

PY - 2010/11

Y1 - 2010/11

N2 - In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case-control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3-171.3 P= 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1-1.5; P= 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.

AB - In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case-control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3-171.3 P= 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1-1.5; P= 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.

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Extensively drug-resistant Acinetobacter baumannii: Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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