Extensively drug-resistant Acinetobacter baumannii

Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study

Yoon Soo Park, Hyukmin Lee, Kkot Sil Lee, Seung Sik Hwang, Yong Kyun Cho, Hyo Youl Kim, Young Uh, Bum Sik Chin, Sang Hoon Han, Seokhoon Jeong, Kyungwon Lee, June Myung Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case-control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3-171.3 P= 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1-1.5; P= 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.

Original languageEnglish
Pages (from-to)430-435
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Volume36
Issue number5
DOIs
Publication statusPublished - 2010 Nov 1

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Acinetobacter baumannii
Multicenter Studies
Cephalosporins
Pharmaceutical Preparations
Statistical Factor Analysis
Inpatients
Odds Ratio
Confidence Intervals
Republic of Korea
Carbapenems
APACHE
Pulsed Field Gel Electrophoresis
Tertiary Healthcare
Tertiary Care Centers
Genes
Case-Control Studies
Control Groups
Asp(5)-oxytocin

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Park, Yoon Soo ; Lee, Hyukmin ; Lee, Kkot Sil ; Hwang, Seung Sik ; Cho, Yong Kyun ; Kim, Hyo Youl ; Uh, Young ; Chin, Bum Sik ; Han, Sang Hoon ; Jeong, Seokhoon ; Lee, Kyungwon ; Kim, June Myung. / Extensively drug-resistant Acinetobacter baumannii : Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study. In: International Journal of Antimicrobial Agents. 2010 ; Vol. 36, No. 5. pp. 430-435.
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abstract = "In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case-control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95{\%} confidence interval (CI) 1.3-171.3 P= 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95{\%} CI 1.1-1.5; P= 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.",
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Extensively drug-resistant Acinetobacter baumannii : Risk factors for acquisition and prevalent OXA-type carbapenemases-a multicentre study. / Park, Yoon Soo; Lee, Hyukmin; Lee, Kkot Sil; Hwang, Seung Sik; Cho, Yong Kyun; Kim, Hyo Youl; Uh, Young; Chin, Bum Sik; Han, Sang Hoon; Jeong, Seokhoon; Lee, Kyungwon; Kim, June Myung.

In: International Journal of Antimicrobial Agents, Vol. 36, No. 5, 01.11.2010, p. 430-435.

Research output: Contribution to journalArticle

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AU - Lee, Kkot Sil

AU - Hwang, Seung Sik

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AU - Kim, Hyo Youl

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AU - Kim, June Myung

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