Extent of late gadolinium enhancement on cardiovascular magnetic resonance imaging and its relation to left ventricular longitudinal functional reserve during exercise in patients with hypertrophic cardiomyopathy

Jeonggeun Moon, Yoo Jin Hong, Young Jin Kim, Chi Young Shim, Yangsoo Jang, Namsik Chung, Seung Yun Cho, Jong Won Ha

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The aim of this study was to investigate whether the extent of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance imaging reflecting myocardial fibrosis correlates with left ventricular (LV) longitudinal function during exercise in hypertrophic cardiomyopathy (HCM). Methods and Results: Mitral annular velocities (E' and S') were measured on echocardiography at rest and during graded bicycle exercise (25W, 3-min increments) in 46 HCM patients (mean age, 53 years; 32 men). LV longitudinal diastolic and systolic functional reserve indices were calculated as ΔE'×E'base and ΔS'×S'base, where ΔE' and ΔS' are the changes in E' and S' from baseline to 50W of exercise, respectively. The patients were divided into 2 groups according to the extent of LGE (as "percentage of LV mass containing LGE": %LV with LGE; range, 0-37%; median, 6%): group 1 (n=23), %LV with LGE <6%, and group 2, %LV with LGE ≥6%. Baseline echocardiographic parameters were similar between the 2 groups, but changes in E' and S' during exercise were smaller in group 2 (ΔE': 2.8±1.8cm/s vs.1.5±1.0cm/s, P=0.007; ΔS': 2.2±1.2cm/s vs. 0.9±0.8cm/s, P<0.0001). LV functional reserve indices were also significantly lower in group 2 (ΔE'×E'base: 12.8±7.7 vs. 5.5±3.4, P=0.001; ΔS'×S'base: 12.6±7.4 vs. 4.7±4.5, P<0.0001). Conclusions: LV longitudinal function during exercise is influenced by the extent of LGE in HCM. Myocardial fibrosis may represent a pathologic substrate that determines LV functional reserve in patients with HCM.

Original languageEnglish
Pages (from-to)1742-1749
Number of pages8
JournalCirculation Journal
Volume77
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Hypertrophic Cardiomyopathy
Gadolinium
Magnetic Resonance Imaging
Exercise
Left Ventricular Function
Fibrosis
Echocardiography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{53793da808bc45f5ae30cb487be24694,
title = "Extent of late gadolinium enhancement on cardiovascular magnetic resonance imaging and its relation to left ventricular longitudinal functional reserve during exercise in patients with hypertrophic cardiomyopathy",
abstract = "Background: The aim of this study was to investigate whether the extent of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance imaging reflecting myocardial fibrosis correlates with left ventricular (LV) longitudinal function during exercise in hypertrophic cardiomyopathy (HCM). Methods and Results: Mitral annular velocities (E' and S') were measured on echocardiography at rest and during graded bicycle exercise (25W, 3-min increments) in 46 HCM patients (mean age, 53 years; 32 men). LV longitudinal diastolic and systolic functional reserve indices were calculated as ΔE'×E'base and ΔS'×S'base, where ΔE' and ΔS' are the changes in E' and S' from baseline to 50W of exercise, respectively. The patients were divided into 2 groups according to the extent of LGE (as {"}percentage of LV mass containing LGE{"}: {\%}LV with LGE; range, 0-37{\%}; median, 6{\%}): group 1 (n=23), {\%}LV with LGE <6{\%}, and group 2, {\%}LV with LGE ≥6{\%}. Baseline echocardiographic parameters were similar between the 2 groups, but changes in E' and S' during exercise were smaller in group 2 (ΔE': 2.8±1.8cm/s vs.1.5±1.0cm/s, P=0.007; ΔS': 2.2±1.2cm/s vs. 0.9±0.8cm/s, P<0.0001). LV functional reserve indices were also significantly lower in group 2 (ΔE'×E'base: 12.8±7.7 vs. 5.5±3.4, P=0.001; ΔS'×S'base: 12.6±7.4 vs. 4.7±4.5, P<0.0001). Conclusions: LV longitudinal function during exercise is influenced by the extent of LGE in HCM. Myocardial fibrosis may represent a pathologic substrate that determines LV functional reserve in patients with HCM.",
author = "Jeonggeun Moon and Hong, {Yoo Jin} and Kim, {Young Jin} and Shim, {Chi Young} and Yangsoo Jang and Namsik Chung and Cho, {Seung Yun} and Ha, {Jong Won}",
year = "2013",
month = "7",
day = "1",
doi = "10.1253/circj.CJ-12-1378",
language = "English",
volume = "77",
pages = "1742--1749",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "7",

}

TY - JOUR

T1 - Extent of late gadolinium enhancement on cardiovascular magnetic resonance imaging and its relation to left ventricular longitudinal functional reserve during exercise in patients with hypertrophic cardiomyopathy

AU - Moon, Jeonggeun

AU - Hong, Yoo Jin

AU - Kim, Young Jin

AU - Shim, Chi Young

AU - Jang, Yangsoo

AU - Chung, Namsik

AU - Cho, Seung Yun

AU - Ha, Jong Won

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Background: The aim of this study was to investigate whether the extent of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance imaging reflecting myocardial fibrosis correlates with left ventricular (LV) longitudinal function during exercise in hypertrophic cardiomyopathy (HCM). Methods and Results: Mitral annular velocities (E' and S') were measured on echocardiography at rest and during graded bicycle exercise (25W, 3-min increments) in 46 HCM patients (mean age, 53 years; 32 men). LV longitudinal diastolic and systolic functional reserve indices were calculated as ΔE'×E'base and ΔS'×S'base, where ΔE' and ΔS' are the changes in E' and S' from baseline to 50W of exercise, respectively. The patients were divided into 2 groups according to the extent of LGE (as "percentage of LV mass containing LGE": %LV with LGE; range, 0-37%; median, 6%): group 1 (n=23), %LV with LGE <6%, and group 2, %LV with LGE ≥6%. Baseline echocardiographic parameters were similar between the 2 groups, but changes in E' and S' during exercise were smaller in group 2 (ΔE': 2.8±1.8cm/s vs.1.5±1.0cm/s, P=0.007; ΔS': 2.2±1.2cm/s vs. 0.9±0.8cm/s, P<0.0001). LV functional reserve indices were also significantly lower in group 2 (ΔE'×E'base: 12.8±7.7 vs. 5.5±3.4, P=0.001; ΔS'×S'base: 12.6±7.4 vs. 4.7±4.5, P<0.0001). Conclusions: LV longitudinal function during exercise is influenced by the extent of LGE in HCM. Myocardial fibrosis may represent a pathologic substrate that determines LV functional reserve in patients with HCM.

AB - Background: The aim of this study was to investigate whether the extent of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance imaging reflecting myocardial fibrosis correlates with left ventricular (LV) longitudinal function during exercise in hypertrophic cardiomyopathy (HCM). Methods and Results: Mitral annular velocities (E' and S') were measured on echocardiography at rest and during graded bicycle exercise (25W, 3-min increments) in 46 HCM patients (mean age, 53 years; 32 men). LV longitudinal diastolic and systolic functional reserve indices were calculated as ΔE'×E'base and ΔS'×S'base, where ΔE' and ΔS' are the changes in E' and S' from baseline to 50W of exercise, respectively. The patients were divided into 2 groups according to the extent of LGE (as "percentage of LV mass containing LGE": %LV with LGE; range, 0-37%; median, 6%): group 1 (n=23), %LV with LGE <6%, and group 2, %LV with LGE ≥6%. Baseline echocardiographic parameters were similar between the 2 groups, but changes in E' and S' during exercise were smaller in group 2 (ΔE': 2.8±1.8cm/s vs.1.5±1.0cm/s, P=0.007; ΔS': 2.2±1.2cm/s vs. 0.9±0.8cm/s, P<0.0001). LV functional reserve indices were also significantly lower in group 2 (ΔE'×E'base: 12.8±7.7 vs. 5.5±3.4, P=0.001; ΔS'×S'base: 12.6±7.4 vs. 4.7±4.5, P<0.0001). Conclusions: LV longitudinal function during exercise is influenced by the extent of LGE in HCM. Myocardial fibrosis may represent a pathologic substrate that determines LV functional reserve in patients with HCM.

UR - http://www.scopus.com/inward/record.url?scp=84879348581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879348581&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-12-1378

DO - 10.1253/circj.CJ-12-1378

M3 - Article

C2 - 23546472

AN - SCOPUS:84879348581

VL - 77

SP - 1742

EP - 1749

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 7

ER -