Extra-stent vascular remodeling in in-stent restenosis after 188 Re-MAG 3 radiation therapy

Myeongki Hong, Seong Wook Park, Dae Hyuk Moon, Seung Jun Oh, Cheol Whan Lee, Young Hak Kim, Jun Hong Kim, Yuanchun Zhang, Jong Min Song, Duk Hyun Kang, Jae Kwan Song, Jae Joong Kim, Seung Jung Park

Research output: Contribution to journalArticle

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Abstract

Background: The effect of β-radiation on extra-stent vascular remodeling in patients with in-stent restenosis has not been studied. The correlation between the extent of extra-stent plaque proliferation and that of intimal hyperplasia (IH) in in-stent restenosis in patients who received β-radiation therapy as well as conventional therapy has also not been studied. Methods: We evaluated the extra-stent remodeling in diffuse in-stent restenosis between a β-radiation therapy patient group ( 188 Re-MAG 3 , n=50) and a control group (n=9) by applying serial intravascular ultrasound (IVUS) analysis. Matching (post-intervention and follow-up) images were acquired at the follow-up lesion site and were available in 44 of 50 patients who received radiation therapy and in seven of nine control patients. Results: There was a significant increase of the external elastic membrane (EEM) area in both groups: 16.4±3.3 mm 2 post-intervention to 17.1±3.3 mm 2 at follow-up, P=0.001 in the radiation therapy group, and 16.8±4.0 mm 2 post-intervention to 17.4±4.1 mm 2 at follow-up, P=0.008 in the control group. There were no statistically significant differences of the Δ EEM area between the two groups: 0.7±0.4 mm 2 in the radiation therapy group vs. 0.6±0.4 mm 2 in the control group, P=0.389. The Δ IH area correlated with the Δ EEM area in the control group (r=0.826, P=0.022), but not in the radiation therapy group (r=0.016, P=0.919). Conclusions: The findings of this IVUS study were that positive remodeling (increased EEM area) occurred equally in both control and irradiated patients with in-stent restenosis. The extent of remodeling was directly in proportion to IH in the control group, but no such relationship existed in the irradiated patient group.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalInternational Journal of Cardiology
Volume92
Issue number2-3
DOIs
Publication statusPublished - 2003 Jan 1

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Stents
Radiotherapy
Tunica Intima
Control Groups
Hyperplasia
Membranes
Radiation Effects
Vascular Remodeling

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Myeongki ; Park, Seong Wook ; Moon, Dae Hyuk ; Oh, Seung Jun ; Lee, Cheol Whan ; Kim, Young Hak ; Kim, Jun Hong ; Zhang, Yuanchun ; Song, Jong Min ; Kang, Duk Hyun ; Song, Jae Kwan ; Kim, Jae Joong ; Park, Seung Jung. / Extra-stent vascular remodeling in in-stent restenosis after 188 Re-MAG 3 radiation therapy In: International Journal of Cardiology. 2003 ; Vol. 92, No. 2-3. pp. 187-191.
@article{a38ab2067a7344d9a3e0eb73a8ced25b,
title = "Extra-stent vascular remodeling in in-stent restenosis after 188 Re-MAG 3 radiation therapy",
abstract = "Background: The effect of β-radiation on extra-stent vascular remodeling in patients with in-stent restenosis has not been studied. The correlation between the extent of extra-stent plaque proliferation and that of intimal hyperplasia (IH) in in-stent restenosis in patients who received β-radiation therapy as well as conventional therapy has also not been studied. Methods: We evaluated the extra-stent remodeling in diffuse in-stent restenosis between a β-radiation therapy patient group ( 188 Re-MAG 3 , n=50) and a control group (n=9) by applying serial intravascular ultrasound (IVUS) analysis. Matching (post-intervention and follow-up) images were acquired at the follow-up lesion site and were available in 44 of 50 patients who received radiation therapy and in seven of nine control patients. Results: There was a significant increase of the external elastic membrane (EEM) area in both groups: 16.4±3.3 mm 2 post-intervention to 17.1±3.3 mm 2 at follow-up, P=0.001 in the radiation therapy group, and 16.8±4.0 mm 2 post-intervention to 17.4±4.1 mm 2 at follow-up, P=0.008 in the control group. There were no statistically significant differences of the Δ EEM area between the two groups: 0.7±0.4 mm 2 in the radiation therapy group vs. 0.6±0.4 mm 2 in the control group, P=0.389. The Δ IH area correlated with the Δ EEM area in the control group (r=0.826, P=0.022), but not in the radiation therapy group (r=0.016, P=0.919). Conclusions: The findings of this IVUS study were that positive remodeling (increased EEM area) occurred equally in both control and irradiated patients with in-stent restenosis. The extent of remodeling was directly in proportion to IH in the control group, but no such relationship existed in the irradiated patient group.",
author = "Myeongki Hong and Park, {Seong Wook} and Moon, {Dae Hyuk} and Oh, {Seung Jun} and Lee, {Cheol Whan} and Kim, {Young Hak} and Kim, {Jun Hong} and Yuanchun Zhang and Song, {Jong Min} and Kang, {Duk Hyun} and Song, {Jae Kwan} and Kim, {Jae Joong} and Park, {Seung Jung}",
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language = "English",
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Hong, M, Park, SW, Moon, DH, Oh, SJ, Lee, CW, Kim, YH, Kim, JH, Zhang, Y, Song, JM, Kang, DH, Song, JK, Kim, JJ & Park, SJ 2003, ' Extra-stent vascular remodeling in in-stent restenosis after 188 Re-MAG 3 radiation therapy ', International Journal of Cardiology, vol. 92, no. 2-3, pp. 187-191. https://doi.org/10.1016/S0167-5273(03)00057-3

Extra-stent vascular remodeling in in-stent restenosis after 188 Re-MAG 3 radiation therapy . / Hong, Myeongki; Park, Seong Wook; Moon, Dae Hyuk; Oh, Seung Jun; Lee, Cheol Whan; Kim, Young Hak; Kim, Jun Hong; Zhang, Yuanchun; Song, Jong Min; Kang, Duk Hyun; Song, Jae Kwan; Kim, Jae Joong; Park, Seung Jung.

In: International Journal of Cardiology, Vol. 92, No. 2-3, 01.01.2003, p. 187-191.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Extra-stent vascular remodeling in in-stent restenosis after 188 Re-MAG 3 radiation therapy

AU - Hong, Myeongki

AU - Park, Seong Wook

AU - Moon, Dae Hyuk

AU - Oh, Seung Jun

AU - Lee, Cheol Whan

AU - Kim, Young Hak

AU - Kim, Jun Hong

AU - Zhang, Yuanchun

AU - Song, Jong Min

AU - Kang, Duk Hyun

AU - Song, Jae Kwan

AU - Kim, Jae Joong

AU - Park, Seung Jung

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Background: The effect of β-radiation on extra-stent vascular remodeling in patients with in-stent restenosis has not been studied. The correlation between the extent of extra-stent plaque proliferation and that of intimal hyperplasia (IH) in in-stent restenosis in patients who received β-radiation therapy as well as conventional therapy has also not been studied. Methods: We evaluated the extra-stent remodeling in diffuse in-stent restenosis between a β-radiation therapy patient group ( 188 Re-MAG 3 , n=50) and a control group (n=9) by applying serial intravascular ultrasound (IVUS) analysis. Matching (post-intervention and follow-up) images were acquired at the follow-up lesion site and were available in 44 of 50 patients who received radiation therapy and in seven of nine control patients. Results: There was a significant increase of the external elastic membrane (EEM) area in both groups: 16.4±3.3 mm 2 post-intervention to 17.1±3.3 mm 2 at follow-up, P=0.001 in the radiation therapy group, and 16.8±4.0 mm 2 post-intervention to 17.4±4.1 mm 2 at follow-up, P=0.008 in the control group. There were no statistically significant differences of the Δ EEM area between the two groups: 0.7±0.4 mm 2 in the radiation therapy group vs. 0.6±0.4 mm 2 in the control group, P=0.389. The Δ IH area correlated with the Δ EEM area in the control group (r=0.826, P=0.022), but not in the radiation therapy group (r=0.016, P=0.919). Conclusions: The findings of this IVUS study were that positive remodeling (increased EEM area) occurred equally in both control and irradiated patients with in-stent restenosis. The extent of remodeling was directly in proportion to IH in the control group, but no such relationship existed in the irradiated patient group.

AB - Background: The effect of β-radiation on extra-stent vascular remodeling in patients with in-stent restenosis has not been studied. The correlation between the extent of extra-stent plaque proliferation and that of intimal hyperplasia (IH) in in-stent restenosis in patients who received β-radiation therapy as well as conventional therapy has also not been studied. Methods: We evaluated the extra-stent remodeling in diffuse in-stent restenosis between a β-radiation therapy patient group ( 188 Re-MAG 3 , n=50) and a control group (n=9) by applying serial intravascular ultrasound (IVUS) analysis. Matching (post-intervention and follow-up) images were acquired at the follow-up lesion site and were available in 44 of 50 patients who received radiation therapy and in seven of nine control patients. Results: There was a significant increase of the external elastic membrane (EEM) area in both groups: 16.4±3.3 mm 2 post-intervention to 17.1±3.3 mm 2 at follow-up, P=0.001 in the radiation therapy group, and 16.8±4.0 mm 2 post-intervention to 17.4±4.1 mm 2 at follow-up, P=0.008 in the control group. There were no statistically significant differences of the Δ EEM area between the two groups: 0.7±0.4 mm 2 in the radiation therapy group vs. 0.6±0.4 mm 2 in the control group, P=0.389. The Δ IH area correlated with the Δ EEM area in the control group (r=0.826, P=0.022), but not in the radiation therapy group (r=0.016, P=0.919). Conclusions: The findings of this IVUS study were that positive remodeling (increased EEM area) occurred equally in both control and irradiated patients with in-stent restenosis. The extent of remodeling was directly in proportion to IH in the control group, but no such relationship existed in the irradiated patient group.

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