Extraaxial neurofibromas versus neurilemmomas

Discrimination with MRI

Won Hee Jee, Soon Nam Oh, Thomas McCauley, Kyung Nam Ryu, Jinsuck Suh, Jeong Hoon Lee, Jung Mi Park, Kyung Ah Chun, Mi Sook Sung, Kijun Kim, Yeon Soo Lee, Yong Koo Kang, In Young Ok, Jung Man Kim

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE. The purpose of our study was to evaluate whether MRI can discriminate between extraaxial neurofibromas and neurilemmomas. MATERIALS AND METHODS. MR images of 52 patients with a pathologically proven extraaxial neurofibroma or neurilemmoma were retrospectively reviewed by observers who were unaware of the surgical results, regarding the presence or absence of individual imaging criteria. MRI findings in 12 patients with a localized neurofibroma and 40 patients with a neurilemmoma were compared using the chi-square test or Fisher's exact test. RESULTS. MRI findings suggestive of neurofibroma (p < 0.05) were a target sign on T2-weighted images (58% in neurofibromas vs 15% in neurilemmomas), central enhancement (75% vs 8%), and a combination of both findings (63% vs 3%). MRI findings suggestive of a neurilemmoma (p < 0.05) were a fascicular appearance on T2-weighted images (25% vs 63%), a thin hyperintense rim on T2-weighted images (8% vs 58%), a combination of both findings (8% vs 48%), and diffuse enhancement (13% vs 67%). No significant difference was seen between neurofibromas and neurilemmomas for a centrally entering and exiting nerve (42% in neurofibromas vs 23% in neurilemmomas), a peripherally entering and exiting nerve (58% vs 77%), a cystic area (38% vs 64%), a low-signal margin (100% vs 100%), peripheral enhancement (13% vs 26%), or a target sign on contrast-enhanced images (11% vs 31%). CONCLUSION. MRI shows features helpful for differentiating extraaxial neurofibromas from neurilemmomas; however, no single finding or combination of findings allows definitive differentiation.

Original languageEnglish
Pages (from-to)629-633
Number of pages5
JournalAmerican Journal of Roentgenology
Volume183
Issue number3
DOIs
Publication statusPublished - 2004 Jan 1

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Neurofibroma
Neurilemmoma
Chi-Square Distribution

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Jee, W. H., Oh, S. N., McCauley, T., Ryu, K. N., Suh, J., Lee, J. H., ... Kim, J. M. (2004). Extraaxial neurofibromas versus neurilemmomas: Discrimination with MRI. American Journal of Roentgenology, 183(3), 629-633. https://doi.org/10.2214/ajr.183.3.1830629
Jee, Won Hee ; Oh, Soon Nam ; McCauley, Thomas ; Ryu, Kyung Nam ; Suh, Jinsuck ; Lee, Jeong Hoon ; Park, Jung Mi ; Chun, Kyung Ah ; Sung, Mi Sook ; Kim, Kijun ; Lee, Yeon Soo ; Kang, Yong Koo ; Ok, In Young ; Kim, Jung Man. / Extraaxial neurofibromas versus neurilemmomas : Discrimination with MRI. In: American Journal of Roentgenology. 2004 ; Vol. 183, No. 3. pp. 629-633.
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title = "Extraaxial neurofibromas versus neurilemmomas: Discrimination with MRI",
abstract = "OBJECTIVE. The purpose of our study was to evaluate whether MRI can discriminate between extraaxial neurofibromas and neurilemmomas. MATERIALS AND METHODS. MR images of 52 patients with a pathologically proven extraaxial neurofibroma or neurilemmoma were retrospectively reviewed by observers who were unaware of the surgical results, regarding the presence or absence of individual imaging criteria. MRI findings in 12 patients with a localized neurofibroma and 40 patients with a neurilemmoma were compared using the chi-square test or Fisher's exact test. RESULTS. MRI findings suggestive of neurofibroma (p < 0.05) were a target sign on T2-weighted images (58{\%} in neurofibromas vs 15{\%} in neurilemmomas), central enhancement (75{\%} vs 8{\%}), and a combination of both findings (63{\%} vs 3{\%}). MRI findings suggestive of a neurilemmoma (p < 0.05) were a fascicular appearance on T2-weighted images (25{\%} vs 63{\%}), a thin hyperintense rim on T2-weighted images (8{\%} vs 58{\%}), a combination of both findings (8{\%} vs 48{\%}), and diffuse enhancement (13{\%} vs 67{\%}). No significant difference was seen between neurofibromas and neurilemmomas for a centrally entering and exiting nerve (42{\%} in neurofibromas vs 23{\%} in neurilemmomas), a peripherally entering and exiting nerve (58{\%} vs 77{\%}), a cystic area (38{\%} vs 64{\%}), a low-signal margin (100{\%} vs 100{\%}), peripheral enhancement (13{\%} vs 26{\%}), or a target sign on contrast-enhanced images (11{\%} vs 31{\%}). CONCLUSION. MRI shows features helpful for differentiating extraaxial neurofibromas from neurilemmomas; however, no single finding or combination of findings allows definitive differentiation.",
author = "Jee, {Won Hee} and Oh, {Soon Nam} and Thomas McCauley and Ryu, {Kyung Nam} and Jinsuck Suh and Lee, {Jeong Hoon} and Park, {Jung Mi} and Chun, {Kyung Ah} and Sung, {Mi Sook} and Kijun Kim and Lee, {Yeon Soo} and Kang, {Yong Koo} and Ok, {In Young} and Kim, {Jung Man}",
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Jee, WH, Oh, SN, McCauley, T, Ryu, KN, Suh, J, Lee, JH, Park, JM, Chun, KA, Sung, MS, Kim, K, Lee, YS, Kang, YK, Ok, IY & Kim, JM 2004, 'Extraaxial neurofibromas versus neurilemmomas: Discrimination with MRI', American Journal of Roentgenology, vol. 183, no. 3, pp. 629-633. https://doi.org/10.2214/ajr.183.3.1830629

Extraaxial neurofibromas versus neurilemmomas : Discrimination with MRI. / Jee, Won Hee; Oh, Soon Nam; McCauley, Thomas; Ryu, Kyung Nam; Suh, Jinsuck; Lee, Jeong Hoon; Park, Jung Mi; Chun, Kyung Ah; Sung, Mi Sook; Kim, Kijun; Lee, Yeon Soo; Kang, Yong Koo; Ok, In Young; Kim, Jung Man.

In: American Journal of Roentgenology, Vol. 183, No. 3, 01.01.2004, p. 629-633.

Research output: Contribution to journalArticle

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T1 - Extraaxial neurofibromas versus neurilemmomas

T2 - Discrimination with MRI

AU - Jee, Won Hee

AU - Oh, Soon Nam

AU - McCauley, Thomas

AU - Ryu, Kyung Nam

AU - Suh, Jinsuck

AU - Lee, Jeong Hoon

AU - Park, Jung Mi

AU - Chun, Kyung Ah

AU - Sung, Mi Sook

AU - Kim, Kijun

AU - Lee, Yeon Soo

AU - Kang, Yong Koo

AU - Ok, In Young

AU - Kim, Jung Man

PY - 2004/1/1

Y1 - 2004/1/1

N2 - OBJECTIVE. The purpose of our study was to evaluate whether MRI can discriminate between extraaxial neurofibromas and neurilemmomas. MATERIALS AND METHODS. MR images of 52 patients with a pathologically proven extraaxial neurofibroma or neurilemmoma were retrospectively reviewed by observers who were unaware of the surgical results, regarding the presence or absence of individual imaging criteria. MRI findings in 12 patients with a localized neurofibroma and 40 patients with a neurilemmoma were compared using the chi-square test or Fisher's exact test. RESULTS. MRI findings suggestive of neurofibroma (p < 0.05) were a target sign on T2-weighted images (58% in neurofibromas vs 15% in neurilemmomas), central enhancement (75% vs 8%), and a combination of both findings (63% vs 3%). MRI findings suggestive of a neurilemmoma (p < 0.05) were a fascicular appearance on T2-weighted images (25% vs 63%), a thin hyperintense rim on T2-weighted images (8% vs 58%), a combination of both findings (8% vs 48%), and diffuse enhancement (13% vs 67%). No significant difference was seen between neurofibromas and neurilemmomas for a centrally entering and exiting nerve (42% in neurofibromas vs 23% in neurilemmomas), a peripherally entering and exiting nerve (58% vs 77%), a cystic area (38% vs 64%), a low-signal margin (100% vs 100%), peripheral enhancement (13% vs 26%), or a target sign on contrast-enhanced images (11% vs 31%). CONCLUSION. MRI shows features helpful for differentiating extraaxial neurofibromas from neurilemmomas; however, no single finding or combination of findings allows definitive differentiation.

AB - OBJECTIVE. The purpose of our study was to evaluate whether MRI can discriminate between extraaxial neurofibromas and neurilemmomas. MATERIALS AND METHODS. MR images of 52 patients with a pathologically proven extraaxial neurofibroma or neurilemmoma were retrospectively reviewed by observers who were unaware of the surgical results, regarding the presence or absence of individual imaging criteria. MRI findings in 12 patients with a localized neurofibroma and 40 patients with a neurilemmoma were compared using the chi-square test or Fisher's exact test. RESULTS. MRI findings suggestive of neurofibroma (p < 0.05) were a target sign on T2-weighted images (58% in neurofibromas vs 15% in neurilemmomas), central enhancement (75% vs 8%), and a combination of both findings (63% vs 3%). MRI findings suggestive of a neurilemmoma (p < 0.05) were a fascicular appearance on T2-weighted images (25% vs 63%), a thin hyperintense rim on T2-weighted images (8% vs 58%), a combination of both findings (8% vs 48%), and diffuse enhancement (13% vs 67%). No significant difference was seen between neurofibromas and neurilemmomas for a centrally entering and exiting nerve (42% in neurofibromas vs 23% in neurilemmomas), a peripherally entering and exiting nerve (58% vs 77%), a cystic area (38% vs 64%), a low-signal margin (100% vs 100%), peripheral enhancement (13% vs 26%), or a target sign on contrast-enhanced images (11% vs 31%). CONCLUSION. MRI shows features helpful for differentiating extraaxial neurofibromas from neurilemmomas; however, no single finding or combination of findings allows definitive differentiation.

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