TY - JOUR
T1 - Extracellular activities of aminoacyl-tRNA synthetases
T2 - new mediators for cell-cell communication.
AU - Son, Sung Hwa
AU - Park, Min Chul
AU - Kim, Sunghoon
PY - 2014
Y1 - 2014
N2 - Over the last decade, many reports have discussed aminoacyl-tRNA synthetases (ARSs) in extracellular space. Now that so many of them are known to be secreted with distinct activities in the broad range of target cells including endothelial, various immune cells, and fibroblasts, they need to be classified as a new family of extracellular signal mediators. In this chapter the identity of the secreted ARSs, receptors, and their physiological and pathological implications will be described.
AB - Over the last decade, many reports have discussed aminoacyl-tRNA synthetases (ARSs) in extracellular space. Now that so many of them are known to be secreted with distinct activities in the broad range of target cells including endothelial, various immune cells, and fibroblasts, they need to be classified as a new family of extracellular signal mediators. In this chapter the identity of the secreted ARSs, receptors, and their physiological and pathological implications will be described.
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U2 - 10.1007/128_2013_476
DO - 10.1007/128_2013_476
M3 - Review article
C2 - 24352603
AN - SCOPUS:84906077291
SN - 0340-1022
VL - 344
SP - 145
EP - 166
JO - Topics in Current Chemistry
JF - Topics in Current Chemistry
ER -