Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
Bibliographical noteFunding Information:
The authors gratefully acknowledge support from the following funding sources: the National Cancer Institute (CA169538 and CA169416 to D.L. and H.P.), the Department of Defense (W81XWH-13-1-0427, W81XWH-13-1-0249, and W81XWH-14-1-0199 to D.L.), the Hartwell Foundation, the Manning Foundation, the Sohn Foundation, the STARR Consortium, the POETIC Consortium, the James Paduano Foundation, The Nancy C. and Daniel P. Paduano Foundation, Alex's Lemonade Stand Foundation, the Champalimaud Foundation, the Children's Cancer and Blood Foundation, the 5th District AHEPA Cancer Research Foundation (all to D.L.), and the Daedalus Fund (Weill Cornell Medicine, to D.L.). H.P. is supported by grants from MINECO (SAF2014-54541-R), ATRES-MEDIA ? AXA, Asociaci?n Espa?ola Contra el C?ncer, WHRI Academy, and Worldwide Cancer Research. B.K.T. was supported by the Jose Carreras Leukemia Foundation (DJCLS R12/06). H.S.K is supported by a Physician-Scientist Program from the Yonsei University College of Medicine. J.M.W. is supported by a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the NIH (T32GM007739) to the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program. The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
© 2016 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Cell Biology
- Cancer Research