Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice

Ki Lee Chang, Kwang Kyun Park, Jae Kwan Hwang, Kook Lee Sang, Won Yoon Chung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cisplatin (cis-diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents used in the treatment of a variety of human solid tumors. However, its clinical use is rather limited as a result of severe nephrotoxicity. The principal objective of this study was to evaluate the protective effect of Prunus persica flesh extract (PPFE) against cisplatin-induced nephrotoxicity in animal models, and whether its use influences the therapeutic efficacy of cisplatin. The administration of PPFE alone significantly inhibited the growth of CT-26 colon carcinoma xenografted onto mice without adverse effects. The combination of PPFE and cisplatin enhanced the inhibitory effect of cisplatin against tumor growth. In a xenograft model involving the repeated administration of low-dose cisplatin for 15 days, and in an acute toxicity model involving a single administration of high-dose cisplatin over a 16 h period, the administration of PPFE in combination with and prior to the cisplatin injection reversed the cisplatin-induced reduction in the kidney weight. PPFE blocked the increases in the serum blood urea nitrogen and creatinine levels associated with the kidney damage. Moreover, the administration of PPFE induced a significant reduction in cisplatin-induced oxidative stress. These results indicate that PPFE may promote the therapeutic efficacy of cisplatin therapy, while attenuating its inherent nephrotoxicity.

Original languageEnglish
Pages (from-to)999-1005
Number of pages7
JournalPhytotherapy Research
Volume23
Issue number7
DOIs
Publication statusPublished - 2009 Jul 1

All Science Journal Classification (ASJC) codes

  • Pharmacology

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