Extraordinary Transmission-based Plasmonic Nanoarrays for Axially Super-Resolved Cell Imaging

Jong ryul Choi, Kyujung Kim, Youngjin Oh, Ah Leum Kim, Sook Young Kim, Jeon Soo Shin, Donghyun Kim

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Extraordinary transmission based axial imaging (EOT-AIM) for cell microscopy is reported. EOT-AIM uses linear arrays of nanoapertures, each of which samples target fluorescence up to a preset axial distance from surface, in combination with wide-field microscopy for acquisition of lateral images. Current design of nanoapertures provides EOT-AIM with axial super-resolution that is as small as 20 nm for a depth range of 500 nm. Experiments were performed for the measurement of the axial distribution of ganglioside in mouse macrophage (RAW264.7) cells using FITC-conjugated cholera toxin subunit B. The results were successfully confirmed with conventional confocal and total internal reflection fluorescence microscopy.

Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalAdvanced Optical Materials
Volume2
Issue number1
DOIs
Publication statusPublished - 2014 Jan

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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