Extravascular manifestations of Takayasu arteritis

Focusing on the features shared with spondyloarthritis

Oh Chan Kwon, Sang Won Lee, YongBeom Park, Ji Seon Oh, Sang Hoon Lee, Seokchan Hong, Chang Keun Lee, Bin Yoo, Yong Gil Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. Methods: TAK patients from two independent cohorts between January 2012 and October 2017 were included in the study. Patient characteristics were retrospectively collected from the electronic dataset. The computed tomography scans of all subjects were reviewed to evaluate the pattern of vascular involvement and presence of sacroiliitis. Clinical findings including uveitis, skin lesions, oral ulcers, arthritis, and inflammatory bowel disease (IBD) were reviewed. Logistic regression analysis was performed to evaluate the association between vascular and extravascular manifestations. Results: For the 268 TAK patients, the mean age at diagnosis was 41.2 ± 14.2 years and 88.1% were female. The extravascular manifestation of TAK was observed in 19.0% of patients, the most common being arthritis including sacroiliitis (11.9%) followed by recurrent oral ulcers (8.6%) and IBD (2.6%). A multivariate logistic regression analysis revealed type IIB vascular involvement (adjusted odds ratio (OR) 2.956, 95% confidence interval (CI) 1.337-6.537, p = 0.007) and the erythrocyte sedimentation rate (ESR) (adjusted OR 1.014, 95% CI 1.003-1.025, p = 0.012) as significantly associated with the presence of axial and peripheral arthritis. Conclusions: Extravascular manifestations of TAK were observed in up to one-fifth of patients. The most common extravascular manifestation was arthritis, which was associated with a type IIB vascular involvement pattern and a high ESR.

Original languageEnglish
Article number142
JournalArthritis Research and Therapy
Volume20
Issue number1
DOIs
Publication statusPublished - 2018 Jul 11

Fingerprint

Takayasu Arteritis
Blood Vessels
Arthritis
Sacroiliitis
Oral Ulcer
Blood Sedimentation
Inflammatory Bowel Diseases
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Uveitis
Tomography
Skin

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Kwon, Oh Chan ; Lee, Sang Won ; Park, YongBeom ; Oh, Ji Seon ; Lee, Sang Hoon ; Hong, Seokchan ; Lee, Chang Keun ; Yoo, Bin ; Kim, Yong Gil. / Extravascular manifestations of Takayasu arteritis : Focusing on the features shared with spondyloarthritis. In: Arthritis Research and Therapy. 2018 ; Vol. 20, No. 1.
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title = "Extravascular manifestations of Takayasu arteritis: Focusing on the features shared with spondyloarthritis",
abstract = "Background: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. Methods: TAK patients from two independent cohorts between January 2012 and October 2017 were included in the study. Patient characteristics were retrospectively collected from the electronic dataset. The computed tomography scans of all subjects were reviewed to evaluate the pattern of vascular involvement and presence of sacroiliitis. Clinical findings including uveitis, skin lesions, oral ulcers, arthritis, and inflammatory bowel disease (IBD) were reviewed. Logistic regression analysis was performed to evaluate the association between vascular and extravascular manifestations. Results: For the 268 TAK patients, the mean age at diagnosis was 41.2 ± 14.2 years and 88.1{\%} were female. The extravascular manifestation of TAK was observed in 19.0{\%} of patients, the most common being arthritis including sacroiliitis (11.9{\%}) followed by recurrent oral ulcers (8.6{\%}) and IBD (2.6{\%}). A multivariate logistic regression analysis revealed type IIB vascular involvement (adjusted odds ratio (OR) 2.956, 95{\%} confidence interval (CI) 1.337-6.537, p = 0.007) and the erythrocyte sedimentation rate (ESR) (adjusted OR 1.014, 95{\%} CI 1.003-1.025, p = 0.012) as significantly associated with the presence of axial and peripheral arthritis. Conclusions: Extravascular manifestations of TAK were observed in up to one-fifth of patients. The most common extravascular manifestation was arthritis, which was associated with a type IIB vascular involvement pattern and a high ESR.",
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Extravascular manifestations of Takayasu arteritis : Focusing on the features shared with spondyloarthritis. / Kwon, Oh Chan; Lee, Sang Won; Park, YongBeom; Oh, Ji Seon; Lee, Sang Hoon; Hong, Seokchan; Lee, Chang Keun; Yoo, Bin; Kim, Yong Gil.

In: Arthritis Research and Therapy, Vol. 20, No. 1, 142, 11.07.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Extravascular manifestations of Takayasu arteritis

T2 - Focusing on the features shared with spondyloarthritis

AU - Kwon, Oh Chan

AU - Lee, Sang Won

AU - Park, YongBeom

AU - Oh, Ji Seon

AU - Lee, Sang Hoon

AU - Hong, Seokchan

AU - Lee, Chang Keun

AU - Yoo, Bin

AU - Kim, Yong Gil

PY - 2018/7/11

Y1 - 2018/7/11

N2 - Background: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. Methods: TAK patients from two independent cohorts between January 2012 and October 2017 were included in the study. Patient characteristics were retrospectively collected from the electronic dataset. The computed tomography scans of all subjects were reviewed to evaluate the pattern of vascular involvement and presence of sacroiliitis. Clinical findings including uveitis, skin lesions, oral ulcers, arthritis, and inflammatory bowel disease (IBD) were reviewed. Logistic regression analysis was performed to evaluate the association between vascular and extravascular manifestations. Results: For the 268 TAK patients, the mean age at diagnosis was 41.2 ± 14.2 years and 88.1% were female. The extravascular manifestation of TAK was observed in 19.0% of patients, the most common being arthritis including sacroiliitis (11.9%) followed by recurrent oral ulcers (8.6%) and IBD (2.6%). A multivariate logistic regression analysis revealed type IIB vascular involvement (adjusted odds ratio (OR) 2.956, 95% confidence interval (CI) 1.337-6.537, p = 0.007) and the erythrocyte sedimentation rate (ESR) (adjusted OR 1.014, 95% CI 1.003-1.025, p = 0.012) as significantly associated with the presence of axial and peripheral arthritis. Conclusions: Extravascular manifestations of TAK were observed in up to one-fifth of patients. The most common extravascular manifestation was arthritis, which was associated with a type IIB vascular involvement pattern and a high ESR.

AB - Background: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. Methods: TAK patients from two independent cohorts between January 2012 and October 2017 were included in the study. Patient characteristics were retrospectively collected from the electronic dataset. The computed tomography scans of all subjects were reviewed to evaluate the pattern of vascular involvement and presence of sacroiliitis. Clinical findings including uveitis, skin lesions, oral ulcers, arthritis, and inflammatory bowel disease (IBD) were reviewed. Logistic regression analysis was performed to evaluate the association between vascular and extravascular manifestations. Results: For the 268 TAK patients, the mean age at diagnosis was 41.2 ± 14.2 years and 88.1% were female. The extravascular manifestation of TAK was observed in 19.0% of patients, the most common being arthritis including sacroiliitis (11.9%) followed by recurrent oral ulcers (8.6%) and IBD (2.6%). A multivariate logistic regression analysis revealed type IIB vascular involvement (adjusted odds ratio (OR) 2.956, 95% confidence interval (CI) 1.337-6.537, p = 0.007) and the erythrocyte sedimentation rate (ESR) (adjusted OR 1.014, 95% CI 1.003-1.025, p = 0.012) as significantly associated with the presence of axial and peripheral arthritis. Conclusions: Extravascular manifestations of TAK were observed in up to one-fifth of patients. The most common extravascular manifestation was arthritis, which was associated with a type IIB vascular involvement pattern and a high ESR.

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U2 - 10.1186/s13075-018-1643-7

DO - 10.1186/s13075-018-1643-7

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