At the anastomosis sites after coronary/peripheral bypass grafting for the treatment of atherosclerosis, intimal hyperplasia which induces restenosis or occlusion is commonly followed. In order to prevent such vascular disease with enhanced drug delivery efficiency, we have previously developed perivascular microneedle(MN) devices including MN cuffs and flexible MN meshes. Although the flexible PLGA MN meshes showed significantly improved drug delivery efficiency and efficacy as well as safety to the injured blood vessel, blood vessels were often damaged when relatively stiff PLGA meshes were tightly applied to the blood vessel. Thus, we have developed mechanically adjusted highly stretchable MN meshes using natural biocompatible silk fibroin (SF) protein for localized and secure perivascular drug delivery (Fig. 1). Subsequently, comparative mechanical characterization using rabbit abdominal aorta, PLGA meshes and SF meshes showed significantly soften tensile strength of SF meshes. Finally, we evaluated the efficiency and safety of SF MN meshes for perivascular drug delivery after in vivo animal study.
|Title of host publication||Society for Biomaterials Annual Meeting and Exposition 2019|
|Subtitle of host publication||The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting|
|Publisher||Society for Biomaterials|
|Number of pages||1|
|Publication status||Published - 2019|
|Event||42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States|
Duration: 2019 Apr 3 → 2019 Apr 6
|Name||Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium|
|Conference||42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence|
|Period||19/4/3 → 19/4/6|
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All Science Journal Classification (ASJC) codes
- Materials Chemistry