Fabrication and characterization of silk fibroin microneedle meshes for perivascular drug delivery

Jiyong Lee, Seung Hyun Park, Eui Hwa Jang, Jung Hwan Kim, Young Nam Youn, Wonhyoung Ryu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

At the anastomosis sites after coronary/peripheral bypass grafting for the treatment of atherosclerosis, intimal hyperplasia which induces restenosis or occlusion is commonly followed. In order to prevent such vascular disease with enhanced drug delivery efficiency, we have previously developed perivascular microneedle(MN) devices including MN cuffs and flexible MN meshes. Although the flexible PLGA MN meshes showed significantly improved drug delivery efficiency and efficacy as well as safety to the injured blood vessel, blood vessels were often damaged when relatively stiff PLGA meshes were tightly applied to the blood vessel. Thus, we have developed mechanically adjusted highly stretchable MN meshes using natural biocompatible silk fibroin (SF) protein for localized and secure perivascular drug delivery (Fig. 1). Subsequently, comparative mechanical characterization using rabbit abdominal aorta, PLGA meshes and SF meshes showed significantly soften tensile strength of SF meshes. Finally, we evaluated the efficiency and safety of SF MN meshes for perivascular drug delivery after in vivo animal study.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019 Jan 1
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19/4/319/4/6

Fingerprint

Fibroins
Silk
Drug delivery
Blood vessels
Blood Vessels
Fabrication
Pharmaceutical Preparations
Tunica Intima
Safety
Tensile Strength
Abdominal Aorta
Vascular Diseases
Hyperplasia
Atherosclerosis
Animals
Tensile strength
Rabbits
Proteins
Equipment and Supplies
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Lee, J., Park, S. H., Jang, E. H., Kim, J. H., Youn, Y. N., & Ryu, W. (2019). Fabrication and characterization of silk fibroin microneedle meshes for perivascular drug delivery. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Lee, Jiyong ; Park, Seung Hyun ; Jang, Eui Hwa ; Kim, Jung Hwan ; Youn, Young Nam ; Ryu, Wonhyoung. / Fabrication and characterization of silk fibroin microneedle meshes for perivascular drug delivery. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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abstract = "At the anastomosis sites after coronary/peripheral bypass grafting for the treatment of atherosclerosis, intimal hyperplasia which induces restenosis or occlusion is commonly followed. In order to prevent such vascular disease with enhanced drug delivery efficiency, we have previously developed perivascular microneedle(MN) devices including MN cuffs and flexible MN meshes. Although the flexible PLGA MN meshes showed significantly improved drug delivery efficiency and efficacy as well as safety to the injured blood vessel, blood vessels were often damaged when relatively stiff PLGA meshes were tightly applied to the blood vessel. Thus, we have developed mechanically adjusted highly stretchable MN meshes using natural biocompatible silk fibroin (SF) protein for localized and secure perivascular drug delivery (Fig. 1). Subsequently, comparative mechanical characterization using rabbit abdominal aorta, PLGA meshes and SF meshes showed significantly soften tensile strength of SF meshes. Finally, we evaluated the efficiency and safety of SF MN meshes for perivascular drug delivery after in vivo animal study.",
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Lee, J, Park, SH, Jang, EH, Kim, JH, Youn, YN & Ryu, W 2019, Fabrication and characterization of silk fibroin microneedle meshes for perivascular drug delivery. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 19/4/3.

Fabrication and characterization of silk fibroin microneedle meshes for perivascular drug delivery. / Lee, Jiyong; Park, Seung Hyun; Jang, Eui Hwa; Kim, Jung Hwan; Youn, Young Nam; Ryu, Wonhyoung.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - At the anastomosis sites after coronary/peripheral bypass grafting for the treatment of atherosclerosis, intimal hyperplasia which induces restenosis or occlusion is commonly followed. In order to prevent such vascular disease with enhanced drug delivery efficiency, we have previously developed perivascular microneedle(MN) devices including MN cuffs and flexible MN meshes. Although the flexible PLGA MN meshes showed significantly improved drug delivery efficiency and efficacy as well as safety to the injured blood vessel, blood vessels were often damaged when relatively stiff PLGA meshes were tightly applied to the blood vessel. Thus, we have developed mechanically adjusted highly stretchable MN meshes using natural biocompatible silk fibroin (SF) protein for localized and secure perivascular drug delivery (Fig. 1). Subsequently, comparative mechanical characterization using rabbit abdominal aorta, PLGA meshes and SF meshes showed significantly soften tensile strength of SF meshes. Finally, we evaluated the efficiency and safety of SF MN meshes for perivascular drug delivery after in vivo animal study.

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M3 - Conference contribution

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Lee J, Park SH, Jang EH, Kim JH, Youn YN, Ryu W. Fabrication and characterization of silk fibroin microneedle meshes for perivascular drug delivery. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).