Fabrication and evaluation of a flexible sieve-type microelectrode array for monitoring the regenerating state of peripheral nerves

Yong Ho Kim, Chung Kun Lee, Yong Jun Kim, Myoungho Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This paper reports the design, fabrication and measurement of a flexible microelectrode array for monitoring the regenerating state of peripheral nerves. Polyimide was used so that the device would have biocompatibility, long-term stability and flexibility. Using a 'stress-free etch-release' scheme, it was possible to fabricate a microelectrode array with a smaller feature size because less geometrical deviation took place compared to that using a mechanical peeling-off method. The diameter of the via holes, which provide a path for regenerating nerve fibers, was 40 μm and 50 μm. In vivo tests were performed by implanting fabricated microelectrode arrays into the sciatic nerves of a rat and into the peroneal nerves of a rabbit using two different implantation methods. One is a direct interfascicular suture technique and the other is a method using a nerve conduit. In both cases, no side effects such as cytotoxicity, neuroma and antigen-antibody reaction were observed. In vitro measurement was carried out to confirm the feasibility of measuring nerve signals. The interfacial impedance between body fluids and microelectrodes was measured. The normalized interfacial impedance was 446 Ω/μm2 at 1 kHz. Signal transfer characteristics were analyzed by applying square waves of various frequencies and magnitudes.

Original languageEnglish
Pages (from-to)139-153
Number of pages15
JournalSensors and Materials
Volume17
Issue number3
Publication statusPublished - 2005 Jan 1

Fingerprint

sieves
Sieves
Microelectrodes
nerves
Fabrication
fabrication
Monitoring
evaluation
Antigen-antibody reactions
Peeling
impedance
Body fluids
Cytotoxicity
nerve fibers
Biocompatibility
Polyimides
peeling
body fluids
square waves
rabbits

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Materials Science(all)

Cite this

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Fabrication and evaluation of a flexible sieve-type microelectrode array for monitoring the regenerating state of peripheral nerves. / Kim, Yong Ho; Lee, Chung Kun; Kim, Yong Jun; Lee, Myoungho.

In: Sensors and Materials, Vol. 17, No. 3, 01.01.2005, p. 139-153.

Research output: Contribution to journalArticle

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