Fabrication of carbohydrate chips for studying protein-carbohydrate interactions

Sungjin Park, Injae Shin

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

A new tool for the high-throughput study of carbohydrate-protein interactions: Maleimide-linked carbohydrates (e.g. 1) were immobilized on thiol-derivatized glass slides, and the microspots were probed with fluorescein-labeled lectins (see picture). The binding of lectins to the carbohydrates on the slide depends on the concentration of the immobilized carbohydrates and on the length of the tethers.

Original languageEnglish
Pages (from-to)3180-3182
Number of pages3
JournalAngewandte Chemie - International Edition
Volume41
Issue number17
DOIs
Publication statusPublished - 2002 Sep 2

Fingerprint

Carbohydrates
Proteins
Fabrication
Lectins
Fluorescein
Sulfhydryl Compounds
Throughput
Glass

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

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Fabrication of carbohydrate chips for studying protein-carbohydrate interactions. / Park, Sungjin; Shin, Injae.

In: Angewandte Chemie - International Edition, Vol. 41, No. 17, 02.09.2002, p. 3180-3182.

Research output: Contribution to journalArticle

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