Fabrication of hollow hydroxyapatite spherical granules for hard tissue regeneration and alternative method for drug release test

Min Ho Hong, Kwang Mahn Kim, Seong Ho Choi, D. S. Oh, Yong Keun Lee

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3 Citations (Scopus)


Hollow hydroxyapatite spherical granules were fabricated using template method. Alginate beads were used as template and they were coated with hydroxyapatite slurry. The coated beads were rapidly frozen using liquid nitrogen and burned out during sintering process. The size of the granules is the range of 1.0-1.5 mm. The shell is about 150 mm thick and the size of pores is about 10 mm in diameter, arranged in radial shape. The inner space and surface of granules were connected by pore channels which were formed by sublimation of water. Simulated body fluid was used to form apatite layer inner wall of granules and evaluated difference of fluid migration rate as concentration of slurry as an alternative drug release test. The possibilities of hollow hydroxyapatite spherical granules as bone grafts and drug carriers were discussed.

Original languageEnglish
Pages (from-to)634-636
Number of pages3
JournalMicro and Nano Letters
Issue number7
Publication statusPublished - 2012 Dec 1


All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics

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