Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Young Bock Shim, Hong Hee Jung, Ju Woong Jang, Hee Seok Yang, Hojae Bae, Jong Chul Park, Bogyu Choi, Soo Hong Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalJournal of Industrial and Engineering Chemistry
Volume37
DOIs
Publication statusPublished - 2016 May 25

Fingerprint

Bone Morphogenetic Protein 2
Sugar (sucrose)
Microspheres
Dexamethasone
Sucrose
Bone
Proteins
Fabrication
Oils
Collagen
Emulsions
Water
Evaporation
Collagen Type I
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

Shim, Young Bock ; Jung, Hong Hee ; Jang, Ju Woong ; Yang, Hee Seok ; Bae, Hojae ; Park, Jong Chul ; Choi, Bogyu ; Lee, Soo Hong. / Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2. In: Journal of Industrial and Engineering Chemistry. 2016 ; Vol. 37. pp. 101-106.
@article{aa6c16bd2898469faefcaed44823f06a,
title = "Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2",
abstract = "Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.",
author = "Shim, {Young Bock} and Jung, {Hong Hee} and Jang, {Ju Woong} and Yang, {Hee Seok} and Hojae Bae and Park, {Jong Chul} and Bogyu Choi and Lee, {Soo Hong}",
year = "2016",
month = "5",
day = "25",
doi = "10.1016/j.jiec.2016.03.014",
language = "English",
volume = "37",
pages = "101--106",
journal = "Journal of Industrial and Engineering Chemistry",
issn = "1226-086X",
publisher = "Korean Society of Industrial Engineering Chemistry",

}

Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2. / Shim, Young Bock; Jung, Hong Hee; Jang, Ju Woong; Yang, Hee Seok; Bae, Hojae; Park, Jong Chul; Choi, Bogyu; Lee, Soo Hong.

In: Journal of Industrial and Engineering Chemistry, Vol. 37, 25.05.2016, p. 101-106.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

AU - Shim, Young Bock

AU - Jung, Hong Hee

AU - Jang, Ju Woong

AU - Yang, Hee Seok

AU - Bae, Hojae

AU - Park, Jong Chul

AU - Choi, Bogyu

AU - Lee, Soo Hong

PY - 2016/5/25

Y1 - 2016/5/25

N2 - Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

AB - Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

UR - http://www.scopus.com/inward/record.url?scp=84977939726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84977939726&partnerID=8YFLogxK

U2 - 10.1016/j.jiec.2016.03.014

DO - 10.1016/j.jiec.2016.03.014

M3 - Article

AN - SCOPUS:84977939726

VL - 37

SP - 101

EP - 106

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

SN - 1226-086X

ER -