Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Young Bock Shim, Hong Hee Jung, Ju Woong Jang, Hee Seok Yang, Hojae Bae, Jong Chul Park, Bogyu Choi, Soo Hong Lee

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Abstract

Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalJournal of Industrial and Engineering Chemistry
Volume37
DOIs
Publication statusPublished - 2016 May 25

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All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

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