Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.
Bibliographical noteFunding Information:
This study was supported by the National Research Foundation of Korea (NRF) grants funded by MSIP ( NRF-2013R1A2A1A09013980 and NRF-2015R1A5A1037656 ) and MEST ( NRF-2014R1A6A3A04055123 ).
© 2016 The Korean Society of Industrial and Engineering Chemistry.
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)