Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Hongkwan Park, Hyunhee Yoo, Taewon Hwang, Tae Joon Park, Dong Hyun Paik, Sung Wook Choi, Jung Hyun Kim

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16 Citations (Scopus)

Abstract

Levofloxacin-loaded nanofibrous scaffolds from chitosan (CS) and poly(ε-caprolactone) (PCL) were prepared using coaxial electrospinning for the controlled release of antibiotics. Levofloxacin was encapsulated in the CS phase as a core and PCL was employed to control the release of levofloxacin as a shell. The levofloxacin-loaded nanofibrous scaffolds prepared at different PCL concentrations (8, 12, 16, and 20 wt%) were characterized by SEM and TEM to confirm their surface morphology and core-shell structure. The nanofibrous scaffold prepared at a higher PCL concentration exhibited higher mechanical properties. In addition, the CS-PCL nanofibrous scaffold exhibited more sustained release of levofloxacin than PCL nanofibrous scaffolds prepared using both single and coaxial nozzles. This levofloxacin-loaded nanofibrous scaffold can potentially be employed for the sustained release of antibiotics after surgical operations.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Pharmaceutical Investigation
Volume42
Issue number2
DOIs
Publication statusPublished - 2012 Apr

Bibliographical note

Funding Information:
Acknowledgements This study was financially supported by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (No. R11-2007-050-00000-0 and R01-2007-000-10353-0), the Nano R&D Program through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science, and Technology (2011-0019176), the Ministry of Knowledge Economy (10030051), the Korea Science and Engineering Foundation (2010-0029220, 2009K001644), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0023064), a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A110416), and a grant from the ‘‘GRRC’’ Project of Gyeonggi Provincial Government, Korea.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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