Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Hongkwan Park, Hyunhee Yoo, Taewon Hwang, Tae Joon Park, Dong Hyun Paik, Sung Wook Choi, Jung-Hyun Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Levofloxacin-loaded nanofibrous scaffolds from chitosan (CS) and poly(ε-caprolactone) (PCL) were prepared using coaxial electrospinning for the controlled release of antibiotics. Levofloxacin was encapsulated in the CS phase as a core and PCL was employed to control the release of levofloxacin as a shell. The levofloxacin-loaded nanofibrous scaffolds prepared at different PCL concentrations (8, 12, 16, and 20 wt%) were characterized by SEM and TEM to confirm their surface morphology and core-shell structure. The nanofibrous scaffold prepared at a higher PCL concentration exhibited higher mechanical properties. In addition, the CS-PCL nanofibrous scaffold exhibited more sustained release of levofloxacin than PCL nanofibrous scaffolds prepared using both single and coaxial nozzles. This levofloxacin-loaded nanofibrous scaffold can potentially be employed for the sustained release of antibiotics after surgical operations.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Pharmaceutical Investigation
Volume42
Issue number2
DOIs
Publication statusPublished - 2012 Apr 1

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Levofloxacin
Chitosan
Anti-Bacterial Agents
polycaprolactone

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

Park, Hongkwan ; Yoo, Hyunhee ; Hwang, Taewon ; Park, Tae Joon ; Paik, Dong Hyun ; Choi, Sung Wook ; Kim, Jung-Hyun. / Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning. In: Journal of Pharmaceutical Investigation. 2012 ; Vol. 42, No. 2. pp. 89-93.
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abstract = "Levofloxacin-loaded nanofibrous scaffolds from chitosan (CS) and poly(ε-caprolactone) (PCL) were prepared using coaxial electrospinning for the controlled release of antibiotics. Levofloxacin was encapsulated in the CS phase as a core and PCL was employed to control the release of levofloxacin as a shell. The levofloxacin-loaded nanofibrous scaffolds prepared at different PCL concentrations (8, 12, 16, and 20 wt{\%}) were characterized by SEM and TEM to confirm their surface morphology and core-shell structure. The nanofibrous scaffold prepared at a higher PCL concentration exhibited higher mechanical properties. In addition, the CS-PCL nanofibrous scaffold exhibited more sustained release of levofloxacin than PCL nanofibrous scaffolds prepared using both single and coaxial nozzles. This levofloxacin-loaded nanofibrous scaffold can potentially be employed for the sustained release of antibiotics after surgical operations.",
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Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning. / Park, Hongkwan; Yoo, Hyunhee; Hwang, Taewon; Park, Tae Joon; Paik, Dong Hyun; Choi, Sung Wook; Kim, Jung-Hyun.

In: Journal of Pharmaceutical Investigation, Vol. 42, No. 2, 01.04.2012, p. 89-93.

Research output: Contribution to journalArticle

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