Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers

Won Hyoung Ryu, Murty Vyakarnam, Ralph S. Greco, Fritz B. Prinz, Rainer J. Fasching

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A programmable and biodegradable drug delivery device is desirable when a drug needs to be administered locally. While most local drug delivery devices made of biodegradable polymers relied on the degradation of the polymers, the degradation-based release control is often limited by the property of the polymers. Thus, we propose micro-geometry as an alternative measure of controlling drug release. The proposed devices consist of three functional layers: diffusion control layer via micro-orifices, diffusion layer, and drug reservoir layers. A micro-fabrication technology was used to shape an array of micro-orifices and micro-cavities in 85/15PLGA layers. A thin layer of fast degrading 50/50PLGA was placed as the diffusion layer between the 85/15PLGA layers to prevent any burst-type release. To modulate the release of the devices, the dimension and location of the micro-orifices were varied and the responding in vitro release response of tetracycline was monitored over 2 weeks. The release response to the different micro-geometry was prominent and further analyzed by FEM simulation. Comparison of the experiments to the simulated results identified that the variation of micro-geometry influenced also the volume-dependent degradation rate and induced the osmotic pressure.

Original languageEnglish
Pages (from-to)845-853
Number of pages9
JournalBiomedical Microdevices
Volume9
Issue number6
DOIs
Publication statusPublished - 2007 Dec

Bibliographical note

Funding Information:
Acknowledgements The authors thank the Center for Biomaterials and Advanced Technologies, a division of Ethicon Inc., Johnson and Johnson Company for the financial and material support.

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Molecular Biology

Fingerprint Dive into the research topics of 'Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers'. Together they form a unique fingerprint.

Cite this