Fabrication of multifunctional layer-by-layer nanocapsules toward the design of theragnostic nanoplatform

Hee Jae Yoon, Tae Geuk Lim, Joo Ho Kim, Young Min Cho, Yong Seok Kim, Ui Seok Chung, Jung Hyun Kim, Byoung Wook Choi, Won Gun Koh, Woo Dong Jang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Self-assembled polymeric nanocapsules (NCs) that incorporate dendrimer porphyrin (DP) in the shells and superparamagnetic iron oxide nanoparticles (SPIONs) in the cores are fabricated to create a theragnostic platform for the application in photodynamic therapy (PDT) and magnetic resonance imaging (MRI). SPIONs-embedded polystyrene NPs (SPIONs@PS) are used as a template to build up multilayered NCs. The formation of PAH/DP multilayer on the SPIONs@PS is monitored by zeta-pential and fluorescence emission measurement, because the porphyrin unit in the core of DP has strong red fluorescence emission. NCs have strong enough magnetic property (>20 emu/g) for MRI application with typical superparamagnetic behavior, where the linear correlation of R2 and Fe concentration at diluted conditions led to corresponding T2 relaxivity coefficient (r2) value of 93.5 mM-1 s-1. Cell viability study upon light irradiation reveals that NCs can successfully work in photosensitizer formulation for PDT.

Original languageEnglish
Pages (from-to)1382-1389
Number of pages8
JournalBiomacromolecules
Volume15
Issue number4
DOIs
Publication statusPublished - 2014 Apr 14

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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