Fabrication of multifunctional layer-by-layer nanocapsules toward the design of theragnostic nanoplatform

Hee Jae Yoon, Tae Geuk Lim, Joo Ho Kim, Young Min Cho, Yong Seok Kim, Ui Seok Chung, Jung-Hyun Kim, Byoung Wook Choi, Won-Gun Koh, Woo Dong Jang

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Self-assembled polymeric nanocapsules (NCs) that incorporate dendrimer porphyrin (DP) in the shells and superparamagnetic iron oxide nanoparticles (SPIONs) in the cores are fabricated to create a theragnostic platform for the application in photodynamic therapy (PDT) and magnetic resonance imaging (MRI). SPIONs-embedded polystyrene NPs (SPIONs@PS) are used as a template to build up multilayered NCs. The formation of PAH/DP multilayer on the SPIONs@PS is monitored by zeta-pential and fluorescence emission measurement, because the porphyrin unit in the core of DP has strong red fluorescence emission. NCs have strong enough magnetic property (>20 emu/g) for MRI application with typical superparamagnetic behavior, where the linear correlation of R2 and Fe concentration at diluted conditions led to corresponding T2 relaxivity coefficient (r2) value of 93.5 mM-1 s-1. Cell viability study upon light irradiation reveals that NCs can successfully work in photosensitizer formulation for PDT.

Original languageEnglish
Pages (from-to)1382-1389
Number of pages8
JournalBiomacromolecules
Volume15
Issue number4
DOIs
Publication statusPublished - 2014 Apr 14

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Nanocapsules
Porphyrins
Dendrimers
Iron oxides
Fabrication
Photodynamic therapy
Magnetic resonance
Nanoparticles
Fluorescence
Imaging techniques
Photosensitizing Agents
Photosensitizers
Polystyrenes
Polycyclic aromatic hydrocarbons
Magnetic properties
Multilayers
Cells
Irradiation
ferric oxide

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Yoon, Hee Jae ; Lim, Tae Geuk ; Kim, Joo Ho ; Cho, Young Min ; Kim, Yong Seok ; Chung, Ui Seok ; Kim, Jung-Hyun ; Choi, Byoung Wook ; Koh, Won-Gun ; Jang, Woo Dong. / Fabrication of multifunctional layer-by-layer nanocapsules toward the design of theragnostic nanoplatform. In: Biomacromolecules. 2014 ; Vol. 15, No. 4. pp. 1382-1389.
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Fabrication of multifunctional layer-by-layer nanocapsules toward the design of theragnostic nanoplatform. / Yoon, Hee Jae; Lim, Tae Geuk; Kim, Joo Ho; Cho, Young Min; Kim, Yong Seok; Chung, Ui Seok; Kim, Jung-Hyun; Choi, Byoung Wook; Koh, Won-Gun; Jang, Woo Dong.

In: Biomacromolecules, Vol. 15, No. 4, 14.04.2014, p. 1382-1389.

Research output: Contribution to journalArticle

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AU - Yoon, Hee Jae

AU - Lim, Tae Geuk

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AU - Cho, Young Min

AU - Kim, Yong Seok

AU - Chung, Ui Seok

AU - Kim, Jung-Hyun

AU - Choi, Byoung Wook

AU - Koh, Won-Gun

AU - Jang, Woo Dong

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