Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids

Seung Hyun Park, Jiyong Lee, Wonhyoung Ryu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: Interstitial fluid (ISF) in the ocular tissue has many biomarkers from ions to proteins. Since the concentration of biomarkers such as lactate and cytokine increase in the presence of cancer, monitoring the level of biomarkers is important to diagnose and treat the diseases. However, there are limited number of tools to collect disease markers from tissue although there are many analytical methods. Herein this study, we developed swellable microneedle (MN) device which was minimally invasive and pain-free to detect the levels of biomarkers from ISF. First, methacrylated hyaluronic acid (MeHA) were synthesized and we fabricated swellable MeHA MNs by a combination of photo-crosslinking and transfer molding. Then, the mechanical stability was confirmed by ex vivo compression tests and in vitro extraction of model biomarkers from phantom tissue was demonstrated.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages364
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19/4/319/4/6

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Park, S. H., Lee, J., & Ryu, W. (2019). Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 364). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.