Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids

Seung Hyun Park; Jiyong Lee; Wonhyoung Ryu

Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids

Seung Hyun Park, Jiyong Lee, Wonhyoung Ryu

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Introduction: Interstitial fluid (ISF) in the ocular tissue has many biomarkers from ions to proteins. Since the concentration of biomarkers such as lactate and cytokine increase in the presence of cancer, monitoring the level of biomarkers is important to diagnose and treat the diseases. However, there are limited number of tools to collect disease markers from tissue although there are many analytical methods. Herein this study, we developed swellable microneedle (MN) device which was minimally invasive and pain-free to detect the levels of biomarkers from ISF. First, methacrylated hyaluronic acid (MeHA) were synthesized and we fabricated swellable MeHA MNs by a combination of photo-crosslinking and transfer molding. Then, the mechanical stability was confirmed by ex vivo compression tests and in vitro extraction of model biomarkers from phantom tissue was demonstrated.

Original language	English
Title of host publication	Society for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publication	The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Publisher	Society for Biomaterials
Pages	364
Number of pages	1
ISBN (Electronic)	9781510883901
Publication status	Published - 2019
Event	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: 2019 Apr 3 → 2019 Apr 6

Publication series

Name	Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume	40
ISSN (Print)	1526-7547

Conference

Conference	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country	United States
City	Seattle
Period	19/4/3 → 19/4/6

All Science Journal Classification (ASJC) codes

Biochemistry
Biophysics
Biotechnology
Biomaterials
Materials Chemistry

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Park, S. H., Lee, J., & Ryu, W. (2019). Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 364). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Park, Seung Hyun ; Lee, Jiyong ; Ryu, Wonhyoung. / Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. pp. 364 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

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title = "Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids",

abstract = "Introduction: Interstitial fluid (ISF) in the ocular tissue has many biomarkers from ions to proteins. Since the concentration of biomarkers such as lactate and cytokine increase in the presence of cancer, monitoring the level of biomarkers is important to diagnose and treat the diseases. However, there are limited number of tools to collect disease markers from tissue although there are many analytical methods. Herein this study, we developed swellable microneedle (MN) device which was minimally invasive and pain-free to detect the levels of biomarkers from ISF. First, methacrylated hyaluronic acid (MeHA) were synthesized and we fabricated swellable MeHA MNs by a combination of photo-crosslinking and transfer molding. Then, the mechanical stability was confirmed by ex vivo compression tests and in vitro extraction of model biomarkers from phantom tissue was demonstrated.",

author = "Park, {Seung Hyun} and Jiyong Lee and Wonhyoung Ryu",

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publisher = "Society for Biomaterials",

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Park, SH, Lee, J & Ryu, W 2019, Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, pp. 364, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 19/4/3.

Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids. / Park, Seung Hyun; Lee, Jiyong; Ryu, Wonhyoung.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. p. 364 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids

AU - Park, Seung Hyun

AU - Lee, Jiyong

AU - Ryu, Wonhyoung

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N2 - Introduction: Interstitial fluid (ISF) in the ocular tissue has many biomarkers from ions to proteins. Since the concentration of biomarkers such as lactate and cytokine increase in the presence of cancer, monitoring the level of biomarkers is important to diagnose and treat the diseases. However, there are limited number of tools to collect disease markers from tissue although there are many analytical methods. Herein this study, we developed swellable microneedle (MN) device which was minimally invasive and pain-free to detect the levels of biomarkers from ISF. First, methacrylated hyaluronic acid (MeHA) were synthesized and we fabricated swellable MeHA MNs by a combination of photo-crosslinking and transfer molding. Then, the mechanical stability was confirmed by ex vivo compression tests and in vitro extraction of model biomarkers from phantom tissue was demonstrated.

AB - Introduction: Interstitial fluid (ISF) in the ocular tissue has many biomarkers from ions to proteins. Since the concentration of biomarkers such as lactate and cytokine increase in the presence of cancer, monitoring the level of biomarkers is important to diagnose and treat the diseases. However, there are limited number of tools to collect disease markers from tissue although there are many analytical methods. Herein this study, we developed swellable microneedle (MN) device which was minimally invasive and pain-free to detect the levels of biomarkers from ISF. First, methacrylated hyaluronic acid (MeHA) were synthesized and we fabricated swellable MeHA MNs by a combination of photo-crosslinking and transfer molding. Then, the mechanical stability was confirmed by ex vivo compression tests and in vitro extraction of model biomarkers from phantom tissue was demonstrated.

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T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

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Park SH, Lee J, Ryu W. Fabrication of swellable microneedle using methacrylated hyaluronic acid for extraction of biomarkers in ocular fluids. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. p. 364. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).