Introduction: Interstitial fluid (ISF) in the ocular tissue has many biomarkers from ions to proteins. Since the concentration of biomarkers such as lactate and cytokine increase in the presence of cancer, monitoring the level of biomarkers is important to diagnose and treat the diseases. However, there are limited number of tools to collect disease markers from tissue although there are many analytical methods. Herein this study, we developed swellable microneedle (MN) device which was minimally invasive and pain-free to detect the levels of biomarkers from ISF. First, methacrylated hyaluronic acid (MeHA) were synthesized and we fabricated swellable MeHA MNs by a combination of photo-crosslinking and transfer molding. Then, the mechanical stability was confirmed by ex vivo compression tests and in vitro extraction of model biomarkers from phantom tissue was demonstrated.
|Title of host publication||Society for Biomaterials Annual Meeting and Exposition 2019|
|Subtitle of host publication||The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting|
|Publisher||Society for Biomaterials|
|Number of pages||1|
|Publication status||Published - 2019|
|Event||42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States|
Duration: 2019 Apr 3 → 2019 Apr 6
|Name||Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium|
|Conference||42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence|
|Period||19/4/3 → 19/4/6|
Bibliographical notePublisher Copyright:
© 2019 Omnipress - All rights reserved.
All Science Journal Classification (ASJC) codes
- Materials Chemistry